Protein Alignment Cyp4d8 and CYP3A4

DIOPT Version :9

• Sequence 1: NP_523961.2
• Gene: Cyp4d8 / 38841
• FlyBaseID: FBgn0015033
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Alignment Length: 496
• Identity: 129/496 - (26%)
• Similarity: 245/496 - (49%)
• Gaps: 61/496 - (12%)

  Fly     1 MLLFLLVVLLFGAGWIIH-----LGQADRRRKVANLPGPICPPLIGAMQLMLRLNPKTFIKVGRE 60
            :||.:.:|||:..|...|     ||          :|||...|.:|.   :|..: |.|.....|
Human    13 LLLAVSLVLLYLYGTHSHGLFKKLG----------IPGPTPLPFLGN---ILSYH-KGFCMFDME 63

  Fly    61 YVLKFGHLQRVWIF---NRLLIMSGDAELNEQLLSSQEHLV---KHPVYKVLGQWLGNGLLLSDG 119
            ...|:|   :||.|   .:.::...|.::.:.:|..:.:.|   :.|...|  .::.:.:.:::.
Human    64 CHKKYG---KVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPV--GFMKSAISIAED 123

  Fly   120 KVWHQRRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKA-NGNTFDVYRSICAAALDIIAETA 183
            :.|.:.|.:::|||....|::.|.:..|..::.|:.|.::| .|....:.....|.::|:|..|:
Human   124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTS 188

  Fly   184 MGTKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLI-RTMQEFTI 247
            .|..|.:..|...|:.|...:   ||.:.|:..:.....:|....|.|:.....:. |.:..|..
Human   189 FGVNIDSLNNPQDPFVENTKK---LLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLR 250

  Fly   248 KVIEKRRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMS-----TVDGRPLTNDEIREEVDTFM 307
            |.:::.:      :|:|.||      .|.|:..|.:::.|     |...:.|::.|:..:...|:
Human   251 KSVKRMK------ESRLEDT------QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFI 303

  Fly   308 FEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKESLRM 372
            |.|::||:|.|||.::||:.||:||.|:.|||..||  ....|.:...:.:::|::.|:.|:||:
Human   304 FAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL--PNKAPPTYDTVLQMEYLDMVVNETLRL 366

  Fly   373 YPPVPIVGRKLQTDFKYTHSVHGDGVIPAGSEIIIGIFGVHRQPETFPNPDEFIPER--HENGSR 435
            :|    :..:|:...|....::| ..||.|..::|..:.:||.|:.:..|::|:|||  .:|...
Human   367 FP----IAMRLERVCKKDVEING-MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN 426

  Fly   436 VAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREYELLP 476
            :.|:...||.:|||||||.:||.:.||:.|.::::.:...|
Human   427 IDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	110/426 (26%)
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	120/460 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840