DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d8 and Cyp26a1

DIOPT Version :9

Sequence 1:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_569092.2	Gene:	Cyp26a1 / 154985	RGDID:	620161	Length:	497	Species:	Rattus norvegicus

Alignment Length:	494	Identity:	132/494 - (26%)
Similarity:	220/494 - (44%)	Gaps:	61/494 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FLLVVLLFGAG---WIIH-LGQADRRRKVANLPGPICPPLIGAMQLMLRLNPKTFIKVGREYVLK 64
            |:|.:|||.|.   |.:: :...||...:...||.:..|..|. .|.:.|..:.|:::.|.   |
  Rat    14 FVLPLLLFLAALKLWDLYCVSSRDRSCALPLPPGTMGFPFFGE-TLQMVLQRRKFLQMKRR---K 74

  Fly    65 FGHLQRVWIFNRLLIMSGDAELNEQLLSSQEHLVK-H---PVYKVLGQWLGNGLLLSDGKVWHQR 125
            :|.:.:..:|.|..:....|:...::|..:..||. |   .|..:||....:.|..|..|   ||
  Rat    75 YGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGAGCLSNLHDSSHK---QR 136

  Fly   126 RKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKANGNTF---DVYRSICAAALDIIAETAMGTK 187
            :|:|...|:...|:.:|.|..::.:.|:::..........   :|.|.:...|:.|:.....|..
  Rat   137 KKVIMQAFNREALQCYVPVIAEEVSGCLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPGPA 201

  Fly   188 IYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLIRTMQEFTIKVIEK 252
              ....:.....||..|.|..|      ..|.:::.|:..:..:|.|  .||....|..|:...:
  Rat   202 --GGGEDEQQLVEAFEEMTRNL------FSLPIDVPFSGLYRGVKAR--NLIHARIEENIRAKIR 256

  Fly   253 RRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMSTVDGRPLTNDEIREEVDTFMFEGHDTTTSA 317
            |.||           |:.|.|.|..:.||  :..|...|..|....:::.....:|.||:||.||
  Rat   257 RLQA-----------AEPDAGCKDALQLL--IEHSWERGERLDMQALKQSSTELLFGGHETTASA 308

  Fly   318 LSFCLHELSRHPEVQAKMLEEIVQ---VLGTDRSRPVSIRDLGELKYMECVIKESLRMYPPVPIV 379
            .:..:..|..:|.|..|:.|||..   :..:.....:.:..|.:|||:.|||||:||:.||||..
  Rat   309 ATSLITYLGLYPHVLQKVREEIKSKGLLCKSHHEDKLDMETLEQLKYIGCVIKETLRLNPPVPGG 373

  Fly   380 GRKLQTDFKYTHSVHGDGV-IPAGSEIIIGIFGVHRQPETFPNPDEFIPERH-----ENGSRVAP 438
            .|.....|:.      :|. ||.|..:|..|...|...::|.|.:||.|:|.     |:.||
  Rat   374 FRVALKTFEL------NGYQIPKGWNVIYSICDTHDVADSFTNKEEFNPDRFTSLHPEDTSR--- 429

  Fly   439 FKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVR--EYELL 475
            |..|||..|.|:|:|::||::.:|:...::.|  :::||
  Rat   430 FSFIPFGGGLRSCVGKEFAKILLKIFTVELARRCDWQLL 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	114/428 (27%)
Cyp26a1	NP_569092.2	p450	43..491	CDD:299894	123/465 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910