Protein Alignment Cyp4d8 and Cyp4a14

DIOPT Version :10

• Sequence 1: NP_523961.2
• Gene: Cyp4d8 / 38841
• FlyBaseID: FBgn0015033
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_031848.1
• Gene: Cyp4a14 / 13119
• MGIID: 1096550
• Length: 507
• Species: Mus musculus
• Alignment Length: 505
• Identity: 154/505 - (30%)
• Similarity: 253/505 - (50%)
• Gaps: 72/505 - (14%)

  Fly    39 LIGAMQLMLRLNPKTFIKVGREYVLK-------------FGH------LQRVWIFNR------LL 78
            |..|:|..||          |:::||             :||      ||::.|:..      |.
Mouse    31 LFKAVQFYLR----------RQWLLKTLQHFPCMPSHWLWGHHLKDKELQQILIWVEKFPSACLQ 85

  Fly    79 IMSGDAELNEQLLSSQEHLVK----------HPVYKVLGQWLGNGLLLSDGKVWHQRRKIITPTF 133
            .:||.   |.::|......||          ..:|:....|:|.||||.:||.|.|.|:::||.|
Mouse    86 CLSGS---NIRVLLYDPDYVKVVLGRSDPKASGIYQFFAPWIGYGLLLLNGKKWFQHRRMLTPAF 147

  Fly   134 HFSILEQFVEVFDQQSNICVQRLAQKANG--NTFDVYRSICAAALDIIAETAMGTKIYAQANEST 196
            |:.||:.:|::.....||.:.:. :|.:|  :..:::..:....||.:.:.|...:...|.:|::
Mouse   148 HYDILKPYVKIMADSVNIMLDKW-EKLDGQDHPLEIFHCVSLMTLDTVMKCAFSYQGSVQLDENS 211

  Fly   197 P-YAEAVNECTALLSWRFMSVYLQVELLFTLTHP-HLKWRQTQLIRTMQEFTIKVIEKRRQALED 259
            . |.:||.:...|..:|..:.:.:..:::.::.. .|.....|:   ..|.|..||:.|:..|::
Mouse   212 KLYTKAVEDLNNLTFFRLRNAFYKYNIIYNMSSDGRLSHHACQI---AHEHTDGVIKMRKSQLQN 273

  Fly   260 QQSKLMDTADEDVGSKRRMALLDVLLMSTVDGR-PLTNDEIREEVDTFMFEGHDTTTSALSFCLH 323
            ::..      :....||.:..||:||.:.::.| .|:::::|.|||||||||||||.|.:|:..:
Mouse   274 EEEL------QKARKKRHLDFLDILLFARMEDRNSLSDEDLRAEVDTFMFEGHDTTASGISWIFY 332

  Fly   324 ELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKESLRMYPPVPIVGRKLQTDFK 388
            .|:.|||.|.:..||:..:||...|  |:...||::.|....|||:||:||||..|.|:|.:...
Mouse   333 ALATHPEHQQRCREEVQSILGDGTS--VTWDHLGQMPYTTMCIKEALRLYPPVISVSRELSSPVT 395

  Fly   389 YTHSVHGDG-VIPAGSEIIIGIFGVHRQPETFPNPDEFIPERHENGSRVAPFKMIPFSAGPRNCI 452
            :.     || .||.|....|.|:|:|..|..:|||..|.|.|....|.......:|||.|.||||
Mouse   396 FP-----DGRSIPKGITATISIYGLHHNPRFWPNPKVFDPSRFAPDSSHHSHAYLPFSGGSRNCI 455

  Fly   453 GQKFAQLEMKMMLAKIVREYELLPMGQRVEC-IVNIVLRSETGFQLGMRK 501
            |::||..|:|:.:|..:..:||||...|:.. |..:||:|:.|..|.::|
Mouse   456 GKQFAMNELKVAVALTLLRFELLPDPTRIPVPIARLVLKSKNGIHLCLKK 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	144/459 (31%)
Cyp4a14	NP_031848.1	CYP4B-like	69..502	CDD:410771	142/452 (31%)