DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d8 and Cyp4a14

DIOPT Version :9

Sequence 1:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_031848.1	Gene:	Cyp4a14 / 13119	MGIID:	1096550	Length:	507	Species:	Mus musculus

Alignment Length:	505	Identity:	154/505 - (30%)
Similarity:	253/505 - (50%)	Gaps:	72/505 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LIGAMQLMLRLNPKTFIKVGREYVLK-------------FGH------LQRVWIFNR------LL 78
            |..|:|..||          |:::||             :||      ||::.|:..      |.
Mouse    31 LFKAVQFYLR----------RQWLLKTLQHFPCMPSHWLWGHHLKDKELQQILIWVEKFPSACLQ 85

  Fly    79 IMSGDAELNEQLLSSQEHLVK----------HPVYKVLGQWLGNGLLLSDGKVWHQRRKIITPTF 133
            .:||.   |.::|......||          ..:|:....|:|.||||.:||.|.|.|:::||.|
Mouse    86 CLSGS---NIRVLLYDPDYVKVVLGRSDPKASGIYQFFAPWIGYGLLLLNGKKWFQHRRMLTPAF 147

  Fly   134 HFSILEQFVEVFDQQSNICVQRLAQKANG--NTFDVYRSICAAALDIIAETAMGTKIYAQANEST 196
            |:.||:.:|::.....||.:.:. :|.:|  :..:::..:....||.:.:.|...:...|.:|::
Mouse   148 HYDILKPYVKIMADSVNIMLDKW-EKLDGQDHPLEIFHCVSLMTLDTVMKCAFSYQGSVQLDENS 211

  Fly   197 P-YAEAVNECTALLSWRFMSVYLQVELLFTLTHP-HLKWRQTQLIRTMQEFTIKVIEKRRQALED 259
            . |.:||.:...|..:|..:.:.:..:::.::.. .|.....|:   ..|.|..||:.|:..|::
Mouse   212 KLYTKAVEDLNNLTFFRLRNAFYKYNIIYNMSSDGRLSHHACQI---AHEHTDGVIKMRKSQLQN 273

  Fly   260 QQSKLMDTADEDVGSKRRMALLDVLLMSTVDGR-PLTNDEIREEVDTFMFEGHDTTTSALSFCLH 323
            ::..      :....||.:..||:||.:.::.| .|:::::|.|||||||||||||.|.:|:..:
Mouse   274 EEEL------QKARKKRHLDFLDILLFARMEDRNSLSDEDLRAEVDTFMFEGHDTTASGISWIFY 332

  Fly   324 ELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKESLRMYPPVPIVGRKLQTDFK 388
            .|:.|||.|.:..||:..:||...|  |:...||::.|....|||:||:||||..|.|:|.:...
Mouse   333 ALATHPEHQQRCREEVQSILGDGTS--VTWDHLGQMPYTTMCIKEALRLYPPVISVSRELSSPVT 395

  Fly   389 YTHSVHGDG-VIPAGSEIIIGIFGVHRQPETFPNPDEFIPERHENGSRVAPFKMIPFSAGPRNCI 452
            :.     || .||.|....|.|:|:|..|..:|||..|.|.|....|.......:|||.|.||||
Mouse   396 FP-----DGRSIPKGITATISIYGLHHNPRFWPNPKVFDPSRFAPDSSHHSHAYLPFSGGSRNCI 455

  Fly   453 GQKFAQLEMKMMLAKIVREYELLPMGQRVEC-IVNIVLRSETGFQLGMRK 501
            |::||..|:|:.:|..:..:||||...|:.. |..:||:|:.|..|.::|
Mouse   456 GKQFAMNELKVAVALTLLRFELLPDPTRIPVPIARLVLKSKNGIHLCLKK 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	144/459 (31%)
Cyp4a14	NP_031848.1	p450	52..501	CDD:278495	144/468 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845059
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750