DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d8 and Cyp3a13

DIOPT Version :9

Sequence 1:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_031845.1	Gene:	Cyp3a13 / 13113	MGIID:	88610	Length:	503	Species:	Mus musculus

Alignment Length:	499	Identity:	133/499 - (26%)
Similarity:	238/499 - (47%)	Gaps:	67/499 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLFLLVVLLFGAGWIIH-----LGQADRRRKVANLPGPICPPLIGAMQLMLRLNPKTFIKVGRE 60
            |||...:|||:..|...|     ||          :|||...|.:|.    :....|.|.:...:
Mouse    13 MLLATSLVLLYLYGTHSHGIFKKLG----------IPGPKPLPFLGT----ILAYQKGFWECDIQ 63

  Fly    61 YVLKFGHLQRVWIFNRLLIMSGDAELNEQLLSSQ--EHLVKHPVYKVLGQWLGNGLLLSDGKVWH 123
            ...|:|.:..::...:.::...|.::.:.:|..:  ........:..:| .|...:.:|:.:.|.
Mouse    64 CHKKYGKMWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRRFGPVG-ILKKAISISENEEWK 127

  Fly   124 QRRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQ-KANGNTFDVYRSICAAALDIIAETAMGTK 187
            :.|.:::|||....|::...:.:|.:::.|:.:.| ...|....:.....|.::|:|..|:.|..
Mouse   128 RIRALLSPTFTSGRLKEMFPIINQFTDVLVRNMRQGLGEGKPTSMKDIFGAYSMDVITATSFGVN 192

  Fly   188 IYAQANESTPYAEAVNECTALLSWR-FMSVYLQVEL------LFTLTHPHLKWRQ-----TQLIR 240
            |.:..|...|:.|.:.:   ||.:. |..::|.|.|      :|...:..|..|.     |..:.
Mouse   193 IDSLNNPQDPFVEKIKK---LLKFDIFDPLFLSVTLFPFLTPVFDALNVSLFPRDVISFFTTSVE 254

  Fly   241 TMQEFTIKVIEKRRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMSTVDGRPLTNDEIREEVDT 305
            .|:|..:|  ||.:|.::..|  ||..:......:...||.||              ||..:...
Mouse   255 RMKENRMK--EKEKQRVDFLQ--LMINSQNYKTKESHKALSDV--------------EIVAQSVI 301

  Fly   306 FMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKESL 370
            |:|.|::||:|||||.|:.|:.||:||.|:.:||...|  ....|.:...|.:::|::.|:.|:|
Mouse   302 FIFAGYETTSSALSFALYLLAIHPDVQKKLQDEIDAAL--PNKAPATYDTLLQMEYLDMVVNETL 364

  Fly   371 RMYPPVPIVGRKLQTDFKYTHSVHGDGV-IPAGSEIIIGIFGVHRQPETFPNPDEFIPER--HEN 432
            |:||....:.|..:||      |..:|: ||.|:.::|..|.:|:.|:.:|.|:||.|||  .:|
Mouse   365 RLYPIAGRLERVCKTD------VEINGLFIPKGTVVMIPTFALHKDPKYWPEPEEFRPERFSKKN 423

  Fly   433 GSRVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREYELLP 476
            ...:.|:..:||.:|||||||.:||.:.||:.|.::::.:.:.|
Mouse   424 QDSINPYMYLPFGSGPRNCIGMRFALINMKVALVRVLQNFTVQP 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	115/429 (27%)
Cyp3a13	NP_031845.1	p450	39..491	CDD:365848	123/463 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840