DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d8 and Cyp19a1

DIOPT Version :9

Sequence 1:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_001335100.1	Gene:	Cyp19a1 / 13075	MGIID:	88587	Length:	503	Species:	Mus musculus

Alignment Length:	498	Identity:	127/498 - (25%)
Similarity:	225/498 - (45%)	Gaps:	100/498 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ANLPGP-IC---PPLIGAMQLMLRLNPKTFIKVG---REYVLKFGHLQRVWIFNRLLIMSGDAEL 86
            :::||| .|   .|||...:.:       ::.:|   ..|...:|...||||       ||:..|
Mouse    45 SSIPGPGYCLGIGPLISHGRFL-------WMGIGSACNYYNKMYGEFMRVWI-------SGEETL 95

  Fly    87 NEQLLSSQEHLVKHPVY------KVLGQWLG---NGLLLSDG-KVWHQRRKIITPTFHFSI---- 137
            .....||..|::||..|      |...|.:|   ||::.::. .:|    :.|.|.|..::
Mouse    96 IISKSSSMFHVMKHSHYISRFGSKRGLQCIGMHENGIIFNNNPSLW----RTIRPFFMKALTGPG 156

  Fly   138 LEQFVEVFDQQSNICVQRLAQKAN--GNTFDV--YRSICAAALDIIAETAMGTKIYAQANESTPY 198
            |.:.|||       ||:.:.|..:  |...|.  |..:......|:.:|:....:....:||...
Mouse   157 LVRMVEV-------CVESIKQHLDRLGEVTDTSGYVDVLTLMRHIMLDTSNMLFLGIPLDESAIV 214

  Fly   199 AEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLIRTMQEFTIKVIEKRR------QAL 257
            .:......|   |:  ::.::..:.|.::..:.|:.::  ::.:::....::||:|      :.|
Mouse   215 KKIQGYFNA---WQ--ALLIKPNIFFKISWLYRKYERS--VKDLKDEIAVLVEKKRHKVSTAEKL 272

  Fly   258 EDQQSKLMDTADEDVGSKRRMALLDVLLMSTVDGRPLTNDEIREEVDTFMFEGHDTTTSALSFCL 322
            ||    .||.|.:.:.::||              ..||.:.:.:.:...:....||.:..|.|.|
Mouse   273 ED----CMDFATDLIFAERR--------------GDLTKENVNQCILEMLIAAPDTMSVTLYFML 319

  Fly   323 HELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKESLRMYPPVPIVGRK-LQTD 386
            ..::.:|||:|.:|:||..|:|   .|.:.|.|:..||.:|..|.||:|..|.|.:|.|: |:.|
Mouse   320 LLVAEYPEVEAAILKEIHTVVG---DRDIKIEDIQNLKVVENFINESMRYQPVVDLVMRRALEDD 381

  Fly   387 FKYTHSVHGDGV-IPAGSEIIIGIFGVHRQPETFPNPDEFIPERHENGSRVAPFKMI-PFSAGPR 449
            ..       ||. :..|:.||:.|..:||. |.||.|:||..|..|..   .|::.. ||..|||
Mouse   382 VI-------DGYPVKKGTNIILNIGRMHRL-EYFPKPNEFTLENFEKN---VPYRYFQPFGFGPR 435

  Fly   450 NCIGQKFAQLEMKMMLAKIVREYELLPMGQRVECIVNIVLRSE 492
            .|.|:..|.:.||::|..::|.:::..:.:|  ||.||..:::
Mouse   436 GCAGKYIAMVMMKVVLVTLLRRFQVKTLQKR--CIENIPKKND 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	118/454 (26%)
Cyp19a1	NP_001335100.1	p450	48..488	CDD:306555	127/495 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845263
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950