Protein Alignment Cyp4d8 and CYP4F22

DIOPT Version :10

• Sequence 1: NP_523961.2
• Gene: Cyp4d8 / 38841
• FlyBaseID: FBgn0015033
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_775754.2
• Gene: CYP4F22 / 126410
• HGNCID: 26820
• Length: 531
• Species: Homo sapiens
• Alignment Length: 515
• Identity: 154/515 - (29%)
• Similarity: 254/515 - (49%)
• Gaps: 90/515 - (17%)

  Fly    44 QLMLRLNPKTFIKVGREYVLKFGHL-------QRVWIFNRL-LIMSGDAELNEQ--LLSSQEH-- 96
            :|:||     |:::.|.:.:....|       :|.|:...| :.:..:|.|.::  :|.:..|
Human    37 RLLLR-----FLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMYLPNEAGLQDEKKVLDNMHHVL 96

  Fly    97 -----------LVKHP-------------------VYKVLGQWLGNGLLLSDGKVWHQRRKIITP 131
                       ::.||                   .|..|..|||:|||||.|..|.:.|:::||
Human    97 LVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLTP 161

  Fly   132 TFHFSILEQFVEVFDQQSNICVQRLAQKANGN--TFDVYRSICAAALDIIAETAMGTKIYAQANE 194
            .|||.||:.::::|:|.::|...:....|.|:  :.|::..|....||.:.:.........| .:
Human   162 AFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQ-EK 225

  Fly   195 STPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLIRTMQEFTIKVIEKRRQALED 259
            .:.|..|:.|.:||...|...::..::.::..:....::||.  ...:..||.:||::||:||..
Human   226 MSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQA--CDMVHHFTTEVIQERRRALRQ 288

  Fly   260 Q---------QSKLMDTADEDVGSKRRMALLDVLLMS-TVDGRPLTNDEIREEVDTFMFEGHDTT 314
            |         |.|.:|             .:||||:: ..||:.|::::||.|.|||||||||||
Human   289 QGAEAWLKAKQGKTLD-------------FIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTT 340

  Fly   315 TSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKESLRMYPPVPIV 379
            :|.:|:.|..|:::||.|.|..|||.:|:.......:...||.:|.:....||||||.||||.:|
Human   341 SSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLV 405

  Fly   380 GRKLQTDFKYTHSVHGDG-VIPAGSEIIIGIFGVHRQPETFP-----NPDEFIPERHENGSRVAP 438
            .|:...|.|..     || :||.|...::.|:|.|..|..:|     ||..|.|   :|..:.:|
Human   406 SRQCTEDIKLP-----DGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDP---DNPQQRSP 462

  Fly   439 FKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREYEL-LPMGQRVECIVNIVLRSETGFQL 497
            ...:||||||||||||.||..|:::::|..:..:.| :...::|.....::||:|.|..|
Human   463 LAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRKPELILRTENGLWL 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	148/491 (30%)
CYP4F22	NP_775754.2	CYP4F	82..523	CDD:410772	144/465 (31%)