DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d8 and CYP4F22

DIOPT Version :9

Sequence 1:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_775754.2	Gene:	CYP4F22 / 126410	HGNCID:	26820	Length:	531	Species:	Homo sapiens

Alignment Length:	515	Identity:	154/515 - (29%)
Similarity:	254/515 - (49%)	Gaps:	90/515 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 QLMLRLNPKTFIKVGREYVLKFGHL-------QRVWIFNRL-LIMSGDAELNEQ--LLSSQEH-- 96
            :|:||     |:::.|.:.:....|       :|.|:...| :.:..:|.|.::  :|.:..|
Human    37 RLLLR-----FLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMYLPNEAGLQDEKKVLDNMHHVL 96

  Fly    97 -----------LVKHP-------------------VYKVLGQWLGNGLLLSDGKVWHQRRKIITP 131
                       ::.||                   .|..|..|||:|||||.|..|.:.|:::||
Human    97 LVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLTP 161

  Fly   132 TFHFSILEQFVEVFDQQSNICVQRLAQKANGN--TFDVYRSICAAALDIIAETAMGTKIYAQANE 194
            .|||.||:.::::|:|.::|...:....|.|:  :.|::..|....||.:.:.........| .:
Human   162 AFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQ-EK 225

  Fly   195 STPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLIRTMQEFTIKVIEKRRQALED 259
            .:.|..|:.|.:||...|...::..::.::..:....::||.  ...:..||.:||::||:||..
Human   226 MSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQA--CDMVHHFTTEVIQERRRALRQ 288

  Fly   260 Q---------QSKLMDTADEDVGSKRRMALLDVLLMS-TVDGRPLTNDEIREEVDTFMFEGHDTT 314
            |         |.|.:|             .:||||:: ..||:.|::::||.|.|||||||||||
Human   289 QGAEAWLKAKQGKTLD-------------FIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTT 340

  Fly   315 TSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKESLRMYPPVPIV 379
            :|.:|:.|..|:::||.|.|..|||.:|:.......:...||.:|.:....||||||.||||.:|
Human   341 SSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLV 405

  Fly   380 GRKLQTDFKYTHSVHGDG-VIPAGSEIIIGIFGVHRQPETFP-----NPDEFIPERHENGSRVAP 438
            .|:...|.|..     || :||.|...::.|:|.|..|..:|     ||..|.|   :|..:.:|
Human   406 SRQCTEDIKLP-----DGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDP---DNPQQRSP 462

  Fly   439 FKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREYEL-LPMGQRVECIVNIVLRSETGFQL 497
            ...:||||||||||||.||..|:::::|..:..:.| :...::|.....::||:|.|..|
Human   463 LAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRKPELILRTENGLWL 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	148/491 (30%)
CYP4F22	NP_775754.2	p450	60..524	CDD:278495	148/487 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154630
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750