DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d8 and CYP46A1

DIOPT Version :9

Sequence 1:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_006659.1	Gene:	CYP46A1 / 10858	HGNCID:	2641	Length:	500	Species:	Homo sapiens

Alignment Length:	506	Identity:	142/506 - (28%)
Similarity:	249/506 - (49%)	Gaps:	70/506 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLFLLVVLLFG-AGWIIHLGQADRRRKVANLPGPICPP-LIGAMQLMLR---LNPKTFIKVGRE 60
            :||...|:|.|| ....:|..    |.:..::|||..|. |:|.:....:   :..:....|..:
Human     6 LLLGSAVLLAFGLCCTFVHRA----RSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLD 66

  Fly    61 YVLKFGHLQRVWIFNRLLIMSGDAELNEQLLSSQEHLVKHPVYK----VLGQWL-GNGLLLS-DG 119
            :..|:|.:.||.:|::..::....|..::.|.|.::.....:|:    |.|:.| |.||:.. :.
Human    67 WAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNY 131

  Fly   120 KVWHQRRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKANGNT-FDVYRSICAAALDIIAETA 183
            :.||::|::|...|..|.|...:|.|::::...|:.|..||:|.| ..:...:...|:||:|:.|
Human   132 ERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAA 196

  Fly   184 MGTKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLIRTMQEFTIK 248
            .|.:.........|.::||.              |.:|.:            |....|:.:|
Human   197 FGMETSMLLGAQKPLSQAVK--------------LMLEGI------------TASRNTLAKF--- 232

  Fly   249 VIEKRRQALEDQQS-KLMDTADEDVGSKRRMAL-------LDVL--LMSTVDGRPLTNDE-IREE 302
            :..||:|..|.::| :.:.....|...:||.||       .|:|  ::...:|  ..:|| :.:.
Human   233 LPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEG--AQDDEGLLDN 295

  Fly   303 VDTFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIK 367
            ..||...||:|:.:.|:|.:.||||.||:.|::..|:.:|:|:  .|.:...|||.|:|:..|:|
Human   296 FVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGS--KRYLDFEDLGRLQYLSQVLK 358

  Fly   368 ESLRMYPPVPIVGRKLQTDFKYTHSVHGDGV-IPAGSEIIIGIFGVHRQPETFPNPDEFIPERHE 431
            ||||:|||.....|.|:.:...      ||| :|..:.::...:.:.|....|.:|..|.|:|..
Human   359 ESLRLYPPAWGTFRLLEEETLI------DGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFG 417

  Fly   432 NGSRVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVR--EYELLPMGQR 480
            .|:....|...|||.|.|:||||:|||:|:|:::||:::  |:.|:| |||
Human   418 PGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVP-GQR 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	126/436 (29%)
CYP46A1	NP_006659.1	p450	34..466	CDD:365848	131/471 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810