Protein Alignment Cyp4d8 and Cyp3a59

DIOPT Version :10

• Sequence 1: NP_523961.2
• Gene: Cyp4d8 / 38841
• FlyBaseID: FBgn0015033
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_001098630.1
• Gene: Cyp3a59 / 100041449
• MGIID: 3769707
• Length: 503
• Species: Mus musculus
• Alignment Length: 498
• Identity: 126/498 - (25%)
• Similarity: 230/498 - (46%)
• Gaps: 72/498 - (14%)

  Fly     2 LLFLLVVLLFGAGWIIHLGQADRRRKVANLPGPICPPLIGAM----QLMLRLNPKTFIKVGREYV 62
            |:|..:...:..|....||          :|||...||.|.:    ..|.:.:...:.|.|
Mouse    19 LVFFYIYGTYSHGLFKKLG----------IPGPKPLPLFGTIFNYFDGMWKFDEDCYKKYG---- 69

  Fly    63 LKFGHLQRVWIF-----NRLLIMSGDAELNEQLLSSQEHLV--KHPVYKVLGQWLGNGLLLSDGK 120
                   ::|.|     ..|.||  |.|:.:.:|..:.:.|  ..|....:| :|...:.:|:.:
Mouse    70 -------KIWGFYVGPKPILAIM--DPEIIKIVLVKECYSVFTNRPTLGPVG-FLKKSITISEDE 124

  Fly   121 VWHQRRKIITPTFHFSILEQFVEVFDQQSNICVQRL-AQKANGNTFDVYRSICAAALDIIAETAM 184
            .|.:.|.:::|||....|::...:..|..:|.|:.| .::..|...::.....|.::|:|..|:.
Mouse   125 EWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKGEPINMKDIFGAYSMDVITGTSF 189

  Fly   185 GTKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLI-RTMQEFTIK 248
            |..|.:..|...|:   |.:...:|.::....:|...:||....|..:.....:. |....|..|
Mouse   190 GVNIDSLNNPQNPF---VQKTKKILKFKIFDPFLLSTILFPFLTPIYEMLNLSIFPRDSMNFFKK 251

  Fly   249 VIEK-RRQALEDQQS------KLMDTADEDVGSKRRMALLDVLLMSTVDGRPLTNDEIREEVDTF 306
            .::: :::.|..:|.      :||.......|.:.:.||.|:              |:..:...|
Mouse   252 FVKRMKKERLASKQKNRVDFLQLMMNTQNSKGQESQKALSDL--------------EMAAQAVIF 302

  Fly   307 MFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKESLR 371
            :|.|:|.|::::|..::||:.||:||.|:.:||.:.|  ....||:...|.:::|::.|:.||||
Mouse   303 IFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTL--PNKAPVTYDALMDMEYLDMVVNESLR 365

  Fly   372 MYPPVPIVGRKLQTDFKYTHSVHGDGV-IPAGSEIIIGIFGVHRQPETFPNPDEFIPER--HENG 433
            :||....:.|..:.|      |..:|| ||.|:.::|.|:.:||.||.:|.|.||.|.|  .||.
Mouse   366 LYPTAIRLERVSKKD------VEINGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPGRFSKENE 424

  Fly   434 SRVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREYELLP 476
            ..:.|:..:||..|||||:..:||.:.||:.:..:::.:.:.|
Mouse   425 GNIDPYIYMPFGNGPRNCLDMRFALISMKLAVIGVLQNFTVQP 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	112/430 (26%)
Cyp3a59	NP_001098630.1	CYP3A	67..492	CDD:410743	114/440 (26%)