DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp316a1 and CYP4F12

DIOPT Version :9

Sequence 1:	NP_648129.2	Gene:	Cyp316a1 / 38840	FlyBaseID:	FBgn0035790	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_076433.3	Gene:	CYP4F12 / 66002	HGNCID:	18857	Length:	524	Species:	Homo sapiens

Alignment Length:	504	Identity:	125/504 - (24%)
Similarity:	218/504 - (43%)	Gaps:	65/504 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 YFRARRQRSLIKNLKGPFTWPLMGAMHKLLFLTPI-NFFQRSTEYLTKYGTFSRCWVFHRL-FIP 80
            |...||.:...:..|..:.|..:|      .:||. ...:.||:....|......|:...: ||.
Human    42 YNNCRRLQCFPQPPKRNWFWGHLG------LITPTEEGLKNSTQMSATYSQGFTVWLGPIIPFIV 100

  Fly    81 LADLELSRQLLENDTHLETGYEL----MKDWLVGGVLMCQSEQWQKRHSLISGLFDKGNLEQLID 141
            |...:..|.:......:.....|    :|.||..|:|:...::|.:...:::..|....|:..|.
Human   101 LCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYIT 165

  Fly   142 LSRHQTEQLLQK---LAKQADQKVFDIWYTVSPIVLDLMVM------TTCGAKPSEEYSKNLKDL 197
            :.......:|.|   ||.:...:: |::..:|.:.||.:..      :.|..:|| ||...:.:|
Human   166 IFNKSANIMLDKWQHLASEGSSRL-DMFEHISLMTLDSLQKCIFSFDSHCQERPS-EYIATILEL 228

  Fly   198 SEIYRKRFLSLQSANRFNYWLSSPFMR-KRQNRLIKRLNDEHNNLMAMHQSQNQLKIENGLDIYQ 261
            |.:..||...:.....|.|:||....| .|..||:....|      |:.:.:.:.....|:|.:
Human   229 SALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTD------AVIRERRRTLPTQGIDDF- 286

  Fly   262 LRPIPLKD---HKSL--LEILLESKDPQ---LTGEEICGELNTCNYLGYQLCSPALCFCLVTIAR 318
                 .||   .|:|  :::||.|||..   |:.|:|..|.:|..:.|:...:..|.:.|..:||
Human   287 -----FKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLAR 346

  Fly   319 NPSVQQKCLDELNLAQIKDQG-----W-DLEKLNYLDAVLHETMRLYPPQVIVGRQLKKDFPYTH 377
            :|..|::|..|:. ..:||:.     | ||.:|.:|...:.|::||:||...:.|...:|.
Human   347 HPEYQERCRQEVQ-ELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDI---- 406

  Fly   378 SIVGDAE-LPCGSEIYINLYELQRNEVRYPKANHFDAQRFLD-------SPPELLSYSLGPRCCP 434
             ::.|.. :|.|....|::..:..|...:|....:|..|| |       ||...:.:|.|||.|.
Human   407 -VLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRF-DPENSKGRSPLAFIPFSAGPRNCI 469

  Fly   435 ARKFSMQLLKTLLAPILANFEVLPYGDEVRLDLRLVLGSSNGFQLALKP 483
            .:.|:|..:|.:||.:|.:|..||...|.|..|.|::.:..|..|.::|
Human   470 GQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp316a1	NP_648129.2	p450	33..466	CDD:299894	116/470 (25%)
CYP4F12	NP_076433.3	p450	52..506	CDD:306555	119/480 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820