DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp316a1 and Cyp4f14

DIOPT Version :9

Sequence 1:	NP_648129.2	Gene:	Cyp316a1 / 38840	FlyBaseID:	FBgn0035790	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_001191262.1	Gene:	Cyp4f14 / 64385	MGIID:	1927669	Length:	524	Species:	Mus musculus

Alignment Length:	486	Identity:	120/486 - (24%)
Similarity:	215/486 - (44%)	Gaps:	65/486 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 WPLMGAMHKLLFLTPINFFQRSTEYLTK-YGTFSR---CWVFHRL-FIPLADLELSRQLLENDTH 96
            | |||.:.   .:||.   ::..:.||: .||:.:   .|:...: .|.|...::.|.:|.....
Mouse    59 W-LMGHVG---MVTPT---EQGLKELTRLVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNASAA 116

  Fly    97 LETG----YELMKDWLVGGVLMCQSEQWQKRHSLISGLFDKGNLEQLIDLSRHQTEQL---LQKL 154
            :...    |.::|.||..|:|:...::|.:...:::..|....|:..:.:....|..:   .|:|
Mouse   117 VALKDVIFYSILKPWLGDGLLVSAGDKWSRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQRL 181

  Fly   155 AKQADQKVFDIWYTVSPIVLDLMVM------TTCGAKPSEEYSKNLKDLSEIYRKR------FLS 207
            ......:: |::..||.:.||.:..      :.|..| |.||...:.:||.:..||      |:.
Mouse   182 ISDGSARL-DMFEHVSLMTLDSLQKCVFSFDSNCQEK-SSEYIAAILELSALVAKRHQQPLMFMD 244

  Fly   208 LQSANRFNYWLSSPFMRKRQNRLIKRLNDEHNNLMAMHQSQNQLKIENGLDIYQLRPIPLKDHKS 272
            |.      |.|:...||.|     |..|..|....|:.:.:::...:.|||.: |:.........
Mouse   245 LL------YNLTPDGMRFR-----KACNVVHEFTDAVIRERHRTLPDQGLDDF-LKSKAKSKTLD 297

  Fly   273 LLEILLESKD---PQLTGEEICGELNTCNYLGYQLCSPALCFCLVTIARNPSVQQKCLDE----L 330
            .:::||.|||   .:|:.|:|..|.:|..:.|:...:..|.:.|..:||:|..|::|..|    |
Mouse   298 FIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQEVQELL 362

  Fly   331 NLAQIKDQGW-DLEKLNYLDAVLHETMRLYPPQVIVGRQLKKDFPYTHSIVGDAE-LPCGSEIYI 393
            ...:.::..| ||.:|.:|...:.|::||:||..::.|...:|.     ::.|.. :|.|....|
Mouse   363 RGREPEEIEWDDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDI-----LLPDGRTIPKGIICLI 422

  Fly   394 NLYELQRNEVRYPKAN-----HFDAQRFLDSPP-ELLSYSLGPRCCPARKFSMQLLKTLLAPILA 452
            :::.:..|...:|...     .||.:...||.| ..:.:|.|||.|..:.|:|..:|..||..|.
Mouse   423 SIFGIHHNPSVWPDPEVYDPFRFDPENIKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLL 487

  Fly   453 NFEVLPYGDEVRLDLRLVLGSSNGFQLALKP 483
            .|.:||...|.|....|:|.:..|..|.::|
Mouse   488 RFRLLPDDKEPRRQPELILRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp316a1	NP_648129.2	p450	33..466	CDD:299894	115/467 (25%)
Cyp4f14	NP_001191262.1	p450	52..511	CDD:365848	117/477 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820