DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp316a1 and Cyp4f40

DIOPT Version :9

Sequence 1:	NP_648129.2	Gene:	Cyp316a1 / 38840	FlyBaseID:	FBgn0035790	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	XP_006524820.1	Gene:	Cyp4f40 / 631304	MGIID:	3645508	Length:	551	Species:	Mus musculus

Alignment Length:	529	Identity:	122/529 - (23%)
Similarity:	215/529 - (40%)	Gaps:	98/529 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 TW----PLMGAMHKLLFLTPINFFQRSTEYLTK-YGTFSRC-------------WVFHRL----- 77
            :|    |:..:...|.||..|::|  ...:||: |..:::|             |.:..|
Mouse    34 SWLGLGPMSASPWLLFFLVGISWF--LARFLTQLYTLYAKCQRLCGFPQPPKKNWFWGHLGMSPP 96

  Fly    78 -------------------------FIPLADL---ELSRQLLENDTHL----ETGYELMKDWLVG 110
                                     .:||..|   ::.|.:|.....:    :..|..:|.||..
Mouse    97 TEEGMKQVTELVTTYPQGFMTWLGPIVPLITLCHPDIIRSVLSASAAVAPKDDIFYSFLKPWLGD 161

  Fly   111 GVLMCQSEQWQKRHSLISGLFDKGNLEQLIDLSRHQTEQLLQK---LAKQADQKVFDIWYTVSPI 172
            |:|:...::|.:...:::..|....|:..:.:....|..:..|   ||.....:: :::..:|.:
Mouse   162 GLLVSAGDKWNRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWLRLASGGSTRL-NMFENISLM 225

  Fly   173 VLDLM------VMTTCGAKPSEEYSKNLKDLSEIYRKRFLSLQSANRFNYWLSSPFMR-KRQNRL 230
            .||.:      ..:.|..||| :|...:.:||.:..||...|.......|.|:...|| .:..||
Mouse   226 TLDTLQKCVFSFNSNCQEKPS-QYIAAILELSTLAVKRNEQLLMHVDLLYRLTPDGMRFYKACRL 289

  Fly   231 IKRLNDEHNNLMAMHQSQNQLKIENGLDIYQLRPIPLKDHKSL--LEILLESKD---PQLTGEEI 290
            :....|     ..:.:.:..|....|.||.:.:    ...|:|  :::||.:||   .:|:.|:|
Mouse   290 VHDFTD-----AVIQERRRTLLKHGGDDIIKAK----AKSKTLDFIDVLLLTKDEDGKELSDEDI 345

  Fly   291 CGELNTCNYLGYQLCSPALCFCLVTIARNPSVQQKCLDE----LNLAQIKDQGW-DLEKLNYLDA 350
            ..|.:|..:.|:...:..|.:.|..:||:|..|::|..|    |.....|:..| ||.:|.:|..
Mouse   346 RAEADTFMFRGHDTTASGLSWILYNLARHPEHQERCRQEVQELLRDRDPKEIEWDDLAQLPFLTM 410

  Fly   351 VLHETMRLYPPQVIVGRQLKKDFPYTHSIVGDAELPCGSEIYINLYELQRNEVRYPKANHFDAQR 415
            .:.|::||:||..:|.|...:|.    |:.....:|.|....||::....|...:.....:|..|
Mouse   411 CIKESLRLHPPVTMVSRCCTQDI----SLPDGRIIPKGVICIINIFGTHHNPTVWRDPEVYDPFR 471

  Fly   416 F------LDSPPELLSYSLGPRCCPARKFSMQLLKTLLAPILANFEVLPYGDEVRLDLRLVLGSS 474
            |      ..||...:.:|.|||.|..:.|:|..:|..||..|..|.:||...|.|....|:|.:.
Mouse   472 FDPENIQARSPLSFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRILPDDKEPRRKPELILRAE 536

  Fly   475 NGFQLALKP 483
            .|..|.::|
Mouse   537 GGLWLRVEP 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp316a1	NP_648129.2	p450	33..466	CDD:299894	117/510 (23%)
Cyp4f40	XP_006524820.1	p450	79..542	CDD:365848	109/477 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820