DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp316a1 and Cyp3a57

DIOPT Version :9

Sequence 1:	NP_648129.2	Gene:	Cyp316a1 / 38840	FlyBaseID:	FBgn0035790	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_001093650.1	Gene:	Cyp3a57 / 622127	MGIID:	3646373	Length:	503	Species:	Mus musculus

Alignment Length:	527	Identity:	117/527 - (22%)
Similarity:	219/527 - (41%)	Gaps:	123/527 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TFICFCLASAFNYFRARRQRSLIKNL--KGPFTWPLMGAMHKLLFLTPINFFQRSTEY----LTK 64
            |::....:..|.|........|.|.|  .||...||.|.:        ||:.....::    ..|
Mouse    11 TWVLLVTSLVFFYIYGTYSHGLFKKLGIPGPKPLPLFGNI--------INYLDGMWKFDDDCYKK 67

  Fly    65 YGTFSRCWVFH---RLFIPLADLELSRQLLENDTHLETGYELMKD--------WLVGGVLMCQSE 118
            ||   :.|.|:   :..:.:.|.|:.:.:|..:.     |.:..:        :|...:.:.:.|
Mouse    68 YG---KIWGFYEGPQPILAIMDPEIIKIVLVKEC-----YSVFTNRRPFGPVGFLKKSITISEDE 124

  Fly   119 QWQKRHSLISGLFDKGNLEQLIDLSRHQTEQLLQKLAKQADQK----VFDIWYTVSPIVLDLMVM 179
            :|::..:|:|..|....|:::..:.|...:.|::.|.::.:::    :.||:...|   :|::..
Mouse   125 EWKRLRTLLSPTFTSSKLKEMFPIMRQYGDILVRNLRREEEKEEPINMKDIFGAYS---MDVITG 186

  Fly   180 TTCGA------KPSEEYSKNLKD-------------------LSEIYRKRFLSL---QSANRFNY 216
            |:||.      .|.:.:.:.:|.                   |:.||....||:   ||.|.|
Mouse   187 TSCGVNIDSLNNPQDPFVQKIKKILKFKFFDPFLLSVVLFPFLTPIYEMLNLSIFPRQSMNFF-- 249

  Fly   217 WLSSPFMRK-RQNRLIKRLNDEHNNLMAMHQSQNQLKIENGLDIYQLRPIPLKDHKSLLEILLES 280
               ..|::| :::||.....:..:.|..|..:||.                 |..:||
Mouse   250 ---KKFVKKMKKDRLDYNQKNRVDFLQLMMNTQNS-----------------KGQESL------- 287

  Fly   281 KDPQLTGEEICGELNTCNYLGYQLCSPALCFCLVTIARNPSVQQKCLDEL-----NLAQIK-DQG 339
              ..|:..|:..:.....:.||...|.::.|.:..:|.:|.||:|..||:     |.|.:. |..
Mouse   288 --KALSDLEMAAQTLIFIFGGYDGTSTSISFIMYELATHPDVQKKLQDEIDRALPNKAPVTYDAL 350

  Fly   340 WDLEKLNYLDAVLHETMRLYPPQVIVGRQLKKDFPYTHSIVGDAELPCGSEIYINLYELQRNEVR 404
            .|:|   |||.|::|::||||....:.|..|||.. .|.:.    :|.|:.:.|.:|.|.|:...
Mouse   351 MDME---YLDMVVNESLRLYPVVSRIDRFSKKDVE-IHGVF----IPKGTIVMIPIYPLHRDPEY 407

  Fly   405 YPKANHFDAQRF-------LDSPPELLSYSLGPRCCPARKFSMQLLKTLLAPILANFEVLPYGDE 462
            :|:...|..:||       :| |...:.:..|||.|...:|::..:|..:..:|.||.|.|. :|
Mouse   408 WPEPEDFCPERFSKENKGNID-PYIYMPFGNGPRNCIGMRFALISVKLAVTGVLQNFTVQPC-EE 470

  Fly   463 VRLDLRL 469
            .::.:::
Mouse   471 TQIPVKI 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp316a1	NP_648129.2	p450	33..466	CDD:299894	111/493 (23%)
Cyp3a57	NP_001093650.1	p450	39..493	CDD:278495	111/499 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010