DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp316a1 and cyp4v8

DIOPT Version :9

Sequence 1:	NP_648129.2	Gene:	Cyp316a1 / 38840	FlyBaseID:	FBgn0035790	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_001071070.1	Gene:	cyp4v8 / 558851	ZFINID:	ZDB-GENE-061103-601	Length:	513	Species:	Danio rerio

Alignment Length:	525	Identity:	126/525 - (24%)
Similarity:	235/525 - (44%)	Gaps:	84/525 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ICFCLASAFNYFRARRQRSLI---KNLKGPF-----TWPLMGAMHKLLFLTPINFFQRSTEYLTK 64
            |||.      |...:..:|.:   |.|| |.     |:|.:|  :.|.|.:..:||.:...|.|:
Zfish    20 ICFA------YITYQLLKSYLHKWKELK-PIPGIGNTFPFIG--NALQFKSNGDFFLQLVGYTTE 75

  Fly    65 Y--GTFSRCWVFHRLFIPLADLELSRQLLENDTHLET--GYELMKDWLVGGVLMCQSEQWQKRHS 125
            :  ....:.|:....|:.|...|....:|.|..|::.  .|:.:..||..|:|....::|::|..
Zfish    76 FQNSPLLKIWIGPIPFLILFHAETVETVLNNPVHIDKAYAYQFLHPWLGTGLLTSTGDKWRRRRK 140

  Fly   126 LISGLFDKGNLEQLIDLSRHQTEQLLQKLAKQADQKVFDIWYTVSPIVLDLMVMTTCG------A 184
            :::..|....|.:.:::...|.|.|::||.|||.:..|:.:..::...||::..|..|      :
Zfish   141 MLTPTFHFSILTEFLEVMNEQAEVLIEKLEKQAGKGPFNCFSHITLCALDIICETAMGKRIYAQS 205

  Fly   185 KPSEEYSKNLKDLSEIYRKRFLSLQSANRFN-YWLSSPFMRKRQNRLIKRLNDEHN-NLMAMH-- 245
            ....||.:.:..:|:|..:|       .|.. ||....:....:.|       ||| :|..:|
Zfish   206 NYDSEYVRTVYRMSDIITRR-------QRMPWYWPDFVYNYVGEGR-------EHNRSLKILHSF 256

  Fly   246 -------QSQNQLKIENGLDIYQLRPIPLKDHKSLLEILLESKD---PQLTGEEICGELNTCNYL 300
                   :::....:|:..:..|    .::..::.|::||::||   ..||.::|..|::|..:.
Zfish   257 TESVINERAEYLSYVESDSESDQ----GMRKRRAFLDMLLKTKDEDGKMLTHKDIQEEVDTFMFE 317

  Fly   301 GYQLCSPALCFCLVTIARNPSVQQKCLDEL------NLAQIKDQGWDLEKLNYLDAVLHETMRLY 359
            |:...:.|:.:.:..:..:|.||:|...||      :...:..:  ||:||.||:.|:.|::||:
Zfish   318 GHDTTAAAMNWAIHLLGSHPEVQRKAQQELFEVFGESERPVNTE--DLKKLRYLECVIKESLRLF 380

  Fly   360 PPQVIVGRQLKKDFPYTHSIVGDAELPCGSEIYINLYELQRNEVRYPKANHFDAQRFLDS----- 419
            |......|.:..|     :.:...::|.|:.|.:..|.|.|:...:|....|..:|||..
Zfish   381 PSVPFFARTICDD-----TQINGFKVPKGTNIVVITYALHRDPRFFPDPEEFRPERFLPENCVGR 440

  Fly   420 -PPELLSYSLGPRCCPARKFSMQLLKTLLAPILANFEVLPYGDEVRLDLR----LVLGSSNGFQL 479
             |...:.:|.|.|.|..::|::...|.:||.||..|.::  ..:.|.:||    |||....|..:
Zfish   441 HPYAYIPFSAGLRNCIGQRFAIMEEKVILAYILRYFNIV--ACQKREELRPLGELVLRPEQGIWI 503

  Fly   480 ALKPR 484
            .|:.|
Zfish   504 TLERR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp316a1	NP_648129.2	p450	33..466	CDD:299894	110/473 (23%)
cyp4v8	NP_001071070.1	p450	44..501	CDD:278495	114/485 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920