DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp316a1 and Cyp4a1

DIOPT Version :9

Sequence 1:	NP_648129.2	Gene:	Cyp316a1 / 38840	FlyBaseID:	FBgn0035790	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_787031.1	Gene:	Cyp4a1 / 50549	RGDID:	68945	Length:	509	Species:	Rattus norvegicus

Alignment Length:	480	Identity:	116/480 - (24%)
Similarity:	205/480 - (42%)	Gaps:	59/480 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PFTW-----PLMGAMHKLLFLTPINFFQRSTEYLTKYGTFSRCWVFHRLFIPLADLELSRQLL-E 92
            ||.|     ...|.......:|.:..|.         ..|.|.:...:.::.:.|.:..:.:| .
  Rat    55 PFHWFFGHKQFQGDKELQQIMTCVENFP---------SAFPRWFWGSKAYLIVYDPDYMKVILGR 110

  Fly    93 NDTHLETGYELMKDWLVGGVLMCQSEQWQKRHSLISGLFDKGNLEQLIDLSRHQTEQLLQKLAKQ 157
            :|......|.|:..|:..|:|:...:.|.:...:::..|....|:..:.........:|.|..:.
  Rat   111 SDPKANGVYRLLAPWIGYGLLLLNGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLMLDKWEQL 175

  Fly   158 ADQ-KVFDIWYTVSPIVLDLMVMTTCGAKPSEEYSKNLK-------DLSEIYRKRFLSLQSANRF 214
            |.| ...:|:..:|.:.||.::........|.:...|.|       :|::::..|..::...|..
  Rat   176 AGQDSSIEIFQHISLMTLDTVMKCAFSHNGSVQVDGNYKSYIQAIGNLNDLFHSRVRNIFHQNDT 240

  Fly   215 NYWLSSP---FMRKRQNRLIKRLNDEHNNLMAMHQSQNQLKIENGLDIYQLRPIPLKDHKSLLEI 276
            .|..||.   |     ||..:..:|..:.::.:.:.|.|       :..:|..:..|.....|:|
  Rat   241 IYNFSSNGHLF-----NRACQLAHDHTDGVIKLRKDQLQ-------NAGELEKVKKKRRLDFLDI 293

  Fly   277 LL----ESKDPQLTGEEICGELNTCNYLGYQLCSPALCFCLVTIARNPSVQQKCLDELN--LAQI 335
            ||    |:.| .|:.:::..|::|..:.|:...:..:.:....:|.:|..||:|.:|:.  |...
  Rat   294 LLLARMENGD-SLSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPEHQQRCREEVQSVLGDG 357

  Fly   336 KDQGWD-LEKLNYLDAVLHETMRLYPPQVIVGRQLKKD--FPYTHSIVGDAELPCGSEIYINLYE 397
            ....|| |:::.|....:.|.:|||||...:.|:|...  ||...|      ||.|.::.:::|.
  Rat   358 SSITWDHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPDGRS------LPKGIQVTLSIYG 416

  Fly   398 LQRNEVRYPKANHFDAQRFL-DSP---PELLSYSLGPRCCPARKFSMQLLKTLLAPILANFEVLP 458
            |..|...:|....||..||. |||   ...|.:|.|.|.|..::|:|..:|.::|..|..||:||
  Rat   417 LHHNPKVWPNPEVFDPSRFAPDSPRHSHSFLPFSGGARNCIGKQFAMSEMKVIVALTLLRFELLP 481

  Fly   459 YGDEVRLDL-RLVLGSSNGFQLALK 482
            ...:|.:.| ||||.|.||..|.||
  Rat   482 DPTKVPIPLPRLVLKSKNGIYLYLK 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp316a1	NP_648129.2	p450	33..466	CDD:299894	105/461 (23%)
Cyp4a1	NP_787031.1	p450	52..503	CDD:278495	113/475 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920