DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp316a1 and Cyp4f40

DIOPT Version :9

Sequence 1:	NP_648129.2	Gene:	Cyp316a1 / 38840	FlyBaseID:	FBgn0035790	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	XP_038935701.1	Gene:	Cyp4f40 / 503122	RGDID:	1559596	Length:	530	Species:	Rattus norvegicus

Alignment Length:	519	Identity:	126/519 - (24%)
Similarity:	222/519 - (42%)	Gaps:	65/519 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FICFCLASAFN-YFRARRQRSLIKNLKGPFTWPLMGAMHKLLFLTP--INFFQRSTEYLTKYGTF 68
            |:..||...:. |.:.:|.....:..|..:.|..:|       ::|  ....::.||.:..|...
  Rat    30 FLTRCLTQIYTLYAKCQRLCGFPQPPKRSWFWGHLG-------MSPPTEEGMKQMTELVATYPQG 87

  Fly    69 SRCWVFHRLFIPLADL---ELSRQLLENDTHL--ETG--YELMKDWLVGGVLMCQSEQWQKRHSL 126
            ...|:  ...:||..|   ::.|.:|.....:  :.|  |..:|.||..|:|:..|::|.:..|:
  Rat    88 FMTWL--GPIVPLITLCHPDIIRSVLSASAAVAPKDGIFYSFLKPWLGDGLLVSASDKWSRHRSM 150

  Fly   127 ISGLFDKGNLEQLIDLSRHQTEQLLQKLAKQAD--QKVFDIWYTVSPIVLDLM------VMTTCG 183
            ::..|....|:..:.:....|..:..|..:.|.  ....|::..:|.:.||.:      ..:.|.
  Rat   151 LTPAFHFNILKPYVKIFNDSTNIMHAKWLRLASGGSAHLDMFENISLMTLDTLQKCVFSFNSNCQ 215

  Fly   184 AKPSEEYSKNLKDLSEIYRKRFLSLQSANRFNYWLSSPFMRKRQNRLIKRLNDEHNNLMAMHQSQ 248
            .||| ||...:.:||.:..||...|.......|.| :|..|    |..|..:..|:...|:.|.:
  Rat   216 EKPS-EYIAAILELSALVVKRNEQLLLHMDLLYRL-TPDGR----RFYKACHLVHDFTYAVIQER 274

  Fly   249 NQ-LKIENGLDIYQLRPIPLKDHKSL--LEILLESKD---PQLTGEEICGELNTCNYLGYQLCSP 307
            .: |....|.|:.:.:    ...|:|  :::||.|||   .:|:.|:|..|.:|..:.|:...:.
  Rat   275 RRTLPKHGGDDVIKAK----AKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTAS 335

  Fly   308 ALCFCLVTIARNPSVQQKCLDEL-NLAQIKDQGW-----------DLEKLNYLDAVLHETMRLYP 360
            .|.:.|..:|::|..|::|..|: .|.:.:|...           ||.:|.:|...:.|::||:|
  Rat   336 GLSWILYNLAKHPEYQERCRQEVQELLRDRDSEEIECSCGVLLRDDLAQLPFLTMCIKESLRLHP 400

  Fly   361 PQVIVGRQLKKDFPYTHSIVGDAELPCGSEIYINLYELQRNEVRYPKANHFDAQRF------LDS 419
            |..:|.|...:|.    |:.....:|.|....||::....|...:.....:|..||      ..|
  Rat   401 PVTMVSRCCTQDI----SLPDGRVIPKGIICIINIFATHHNPTVWQDPEVYDPFRFDPENIQARS 461

  Fly   420 PPELLSYSLGPRCCPARKFSMQLLKTLLAPILANFEVLPYGDEVRLDLRLVLGSSNGFQLALKP 483
            |...:.:|.|||.|..:.|:|..:|..:|..|..|.|||...|.|....|:|.:.:|..|.::|
  Rat   462 PLAFIPFSAGPRNCIGQTFAMNEMKVAVALTLLRFRVLPDDKEPRRKPELILRAEDGLWLRVEP 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp316a1	NP_648129.2	p450	33..466	CDD:299894	115/473 (24%)
Cyp4f40	XP_038935701.1	CYP4F	74..522	CDD:410772	115/463 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820