DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp316a1 and Cyp4f17

DIOPT Version :9

Sequence 1:	NP_648129.2	Gene:	Cyp316a1 / 38840	FlyBaseID:	FBgn0035790	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_001178915.1	Gene:	Cyp4f17 / 500801	RGDID:	1561655	Length:	524	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	122/529 - (23%)
Similarity:	227/529 - (42%)	Gaps:	86/529 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ILTATFICFCLASAFNYFRARRQRSLIKNLKGPFTWPLMGAMHKLLFLTPINFFQRSTEYLTKYG 66
            :|.|..:.:..|...||.|.|             .:|...:.|  .|...:|..:.:.|.|....
  Rat    29 LLLARILAWISAFYDNYCRLR-------------CFPQPPSRH--WFWGHLNLVKNNEEGLQLLA 78

  Fly    67 TFSR-------CWVFHRLFIPLADL---ELSRQLLENDTHLETG----YELMKDWLVGGVLMCQS 117
            ..|.       ||:  .:|.|:..|   :....:|:....:...    |..:|.||..|:|:...
  Rat    79 EMSHQFQDIHLCWI--GIFYPILRLIHPKFIGPILQAPAAVAPKEMIFYGFLKPWLGDGLLVSAG 141

  Fly   118 EQWQKRHSLISGLFD-------KGNLEQLIDLSRHQTEQLLQKLAKQADQKVFDIWYTVSPIVLD 175
            |:|.::..|::..|.       ..|..:.:::...:.::|..|.:.:     .|::..:|.:.||
  Rat   142 EKWSRQRRLLTPAFHFDILKPYVKNFNKSVNIMHAKWQRLTAKGSAR-----LDMFEHISLMTLD 201

  Fly   176 LMVM------TTCGAKPSEEYSKNLKDLSEIYRKR----FLSLQSANRFNYWLSSPFMRKRQNRL 230
            .:..      :.|...|| ||...:::||.:..||    ||.:.    |.|:|::...|.|
  Rat   202 SLQKCVFSFDSNCQESPS-EYIAAIQELSSLIVKRHHQPFLYMD----FLYYLTADGRRFR---- 257

  Fly   231 IKRLNDEHNNLMAMHQSQNQLKIENGLDIYQLRPIPLKDHKSLLEILLESKD---PQLTGEEICG 292
             |..:..||...|:.:.:.:......:|.: |:..........:::||.:||   .:|:.|:|..
  Rat   258 -KACDLVHNFTDAVIRERRRTLSSQSVDEF-LKSKTKSKTLDFIDVLLLAKDEHGKELSDEDIRA 320

  Fly   293 ELNTCNYLGYQLCSPALCFCLVTIARNPSVQQKCLDELNLAQIKDQ-----GW-DLEKLNYLDAV 351
            |.:|..:.|:...:.||.:.|..:||:|..|::|..|:. ..::|:     .| ||.:|.:|...
  Rat   321 EADTFMFGGHDTTASALSWILYNLARHPEHQERCRQEVR-ELLRDREPEEIEWDDLTQLPFLTMC 384

  Fly   352 LHETMRLYPPQVIVGRQLKKDFPYTHSIVGDAE-LPCGSEIYINLYELQRNEVRYPKANHFDAQR 415
            :.|::||:||..::.|...:|.     ::.|.. :|.|::..|:::.:..|...:|....:|..|
  Rat   385 IKESLRLHPPVTVISRCCTQDV-----VLPDGRVIPKGNDCIISIFGVHHNPSVWPDPEVYDPFR 444

  Fly   416 F------LDSPPELLSYSLGPRCCPARKFSMQLLKTLLAPILANFEVLPYGDEVRLDLRLVLGSS 474
            |      ..||...:.:|.|||.|..:.|:|..:|..:|..|..|.:||...|.|....|:|.:.
  Rat   445 FDSENPQKRSPLAFIPFSAGPRNCIGQTFAMNEMKVAVALTLLRFRLLPDDKEPRRKPELILRAE 509

  Fly   475 NGFQLALKP 483
            .|..|.::|
  Rat   510 GGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp316a1	NP_648129.2	p450	33..466	CDD:299894	110/479 (23%)
Cyp4f17	NP_001178915.1	p450	52..514	CDD:278495	113/487 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820