DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp316a1 and Cyp4e3

DIOPT Version :9

Sequence 1:	NP_648129.2	Gene:	Cyp316a1 / 38840	FlyBaseID:	FBgn0035790	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	131/534 - (24%)
Similarity:	223/534 - (41%)	Gaps:	94/534 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 YF--RARRQRSLIKNLKGPFTWPLMGAMHKLLFLTPINFFQRSTEYLTKYGTFS-RCWVFHRLFI 79
            ||  :|.::|.|:|...||...|::|..:: :...|........::...||..: ..|:.:...|
  Fly    18 YFERKASQRRQLLKEFNGPTPVPILGNANR-IGKNPAEILSTFFDWWYDYGKDNFLFWIGYSSHI 81

  Fly    80 PLAD---LEL---SRQLLENDTHLETGYELMKDWLVGGVLMCQSEQWQKRHSLISGLFDKGNLEQ 138
            .:.:   ||.   |:||::..|.    |:|:..||..|:|.....:|.|...:|:..|....|:.
  Fly    82 VMTNPKQLEYILNSQQLIQKSTI----YDLLHPWLGHGLLTSFGSKWHKHRKMITPSFHFNILQD 142

  Fly   139 LIDLSRHQTEQLLQKLAK-QADQKVFDIWYTVSPIVLDLMVMTTCGAKPSEEYSKNLKDLSEIYR 202
            ..::....:.:.:.:|.| .|...:.|.....:.:.||::..|..|. |.....:....:.:.:|
  Fly   143 FHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVICDTAMGV-PINAMEQRDSSIVQAFR 206

  Fly   203 KRFLSLQSANRFNYWLSSPFMRKRQNRL-------------IKRLNDEHNNLMAMHQSQNQLKIE 254
            ....::      |.....||  ||.||:             :|.|.|...:::    .:....::
  Fly   207 DMCYNI------NMRAFHPF--KRSNRVFSLTPEFSAYQKTLKTLQDFTYDII----EKRVYALQ 259

  Fly   255 NGLDIYQLRPIPLKDHKSLLEILLES--KDPQLTGEEICGELNTCNYLGYQLCSPALCFCLVTIA 317
            ||.......|...:...:.|:.||.|  ....||.:||..|::|..:.|:...:..:.|.:..::
  Fly   260 NGGSKEDHDPSLPRKKMAFLDTLLSSTIDGRPLTRQEIYEEVSTFMFEGHDTTTSGVSFSVYLLS 324

  Fly   318 RNPSVQQKCLDELNLAQIKDQGWDLE---------KLNYLDAVLHETMRLYPPQVIVGRQLKKDF 373
            |:|.||:|...|    |.:..|.|:.         |:.|||..:.|..|:||....:||...||:
  Fly   325 RHPDVQRKLYRE----QCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPFIGRYCDKDY 385

  Fly   374 PYTHSIVGDAELPCGSEIYINLYELQRNEVRYPKANHFDAQRFLDSPP---ELLSYSLGPRCCPA 435
            ....|||     |.|:.:.:.|..|..|:..:...:||..:||.:..|   |.|.:|.|||.|..
  Fly   386 DINGSIV-----PKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKPAPFEYLPFSAGPRNCIG 445

  Fly   436 RKFSMQLLKTLLAPILANFEVLPYGDE-VRLDLR-----------------------------LV 470
            :||::..|||:::.::.:|||||..|| |..|.|                             |.
  Fly   446 QKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREAGRHKYDPILSAVLT 510

  Fly   471 LGSSNGFQLALKPR 484
            |.|.||..|.|:.|
  Fly   511 LKSDNGLHLRLRER 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp316a1	NP_648129.2	p450	33..466	CDD:299894	115/468 (25%)
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	110/459 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I1639
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.970