DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp316a1 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_648129.2	Gene:	Cyp316a1 / 38840	FlyBaseID:	FBgn0035790	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_796281.1	Gene:	Cyp4f39 / 320997	MGIID:	2445210	Length:	532	Species:	Mus musculus

Alignment Length:	523	Identity:	122/523 - (23%)
Similarity:	223/523 - (42%)	Gaps:	63/523 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MILTATFICFCLASAFNYFR----ARRQRSLIKNLKGPFTWPLMGAMHKLLFLTPINFFQRSTEY 61
            ::|...|....|..||..|.    ..|:.|......|.. | |:|  |..::|......|...:.
Mouse    28 LLLVLFFFFRLLVRAFKLFSDFRITCRKLSCFPEPPGRH-W-LLG--HMSMYLPNEKGLQNEKKV 88

  Fly    62 LTKYGTFSRCWVFHRLFIPL----------ADLELSRQLLENDTHLETGYELMKDWLVGGVLMCQ 116
            |.........||  ..|:||          ..|..|..:...|   |..|..:|.||..|:|:.:
Mouse    89 LDTMHHIILAWV--GPFLPLLVLVHPDYIKPVLGASAAIAPKD---EFFYSFLKPWLGDGLLISK 148

  Fly   117 SEQWQKRHSLISGLFDKGNLEQLIDLSRHQTEQLLQKLAKQ-ADQKV--FDIWYTVSPIVLDLM- 177
            ..:|.:...|::..|....|:..:.:....|..:..|..:. |:..|  ||::..:|.:.||.:
Mouse   149 GNKWSRHRRLLTPAFHFDILKPYMKIFNQCTNIMHAKWRRHLAEGSVTSFDMFEHISLMTLDSLQ 213

  Fly   178 -----VMTTCGAKPSEEYSKNLKDLSEIYRKRFLSLQSANRFNYWLSSPFMRKRQNRLIKRLNDE 237
                 ..:.|..:.| :|..::.:||.:..:|...|.....|.|:|::...|.||     ..:..
Mouse   214 KCVFSYNSDCQERMS-DYISSIIELSALVVRRQYRLHHYLDFMYYLTADGRRFRQ-----ACDTV 272

  Fly   238 HNNLMAMHQSQNQLKIENGLDIYQLRPIPLKDHKSL--LEILLESKD---PQLTGEEICGELNTC 297
            ||....:.|.:.|...:.|.:.:    :..|..|:|  :::||.:||   .:|:.|:|..|.:|.
Mouse   273 HNFTTEVIQERRQALRQQGAEAW----LKAKQGKTLDFIDVLLLAKDEEGKELSDEDIRAEADTF 333

  Fly   298 NYLGYQLCSPALCFCLVTIARNPSVQQKCLDELNLA----QIKDQGW-DLEKLNYLDAVLHETMR 357
            .:.|:...|..|.:.|..:|:.|..|:||.:|:...    ::::..| ||.:|.:....:.|::|
Mouse   334 MFEGHDTTSSGLSWALFNLAKYPEYQEKCREEIQEVMKGRELEELDWDDLTQLPFTTMCIKESLR 398

  Fly   358 LYPPQVIVGRQLKKDFPYTHSIVGDAELPCGSEIYINLYELQRNEVRYPKANHFDAQRF------ 416
            .:||..::.|:..:|.......|    :|.|....:::|....|.:.:|.:..::..||
Mouse   399 QFPPVTLISRRCTEDIKLPDGRV----IPKGIICLVSIYGTHHNPIVWPDSKVYNPYRFDPDTPQ 459

  Fly   417 LDSPPELLSYSLGPRCCPARKFSMQLLKTLLAPILANFEV-LPYGDEVRLDLRLVLGSSNGFQLA 480
            ..||...:.:|.|||.|..:.|:|..::.::|..|..|.: :....:||....|:|.:.||..|.
Mouse   460 QRSPLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLLRFRLSVDRTHKVRRKPELILRTENGLWLN 524

  Fly   481 LKP 483
            ::|
Mouse   525 VEP 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp316a1	NP_648129.2	p450	33..466	CDD:299894	108/468 (23%)
Cyp4f39	NP_796281.1	p450	60..515	CDD:365848	109/477 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820