DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp316a1 and Cyp4d1

DIOPT Version :9

Sequence 1:	NP_648129.2	Gene:	Cyp316a1 / 38840	FlyBaseID:	FBgn0035790	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	126/523 - (24%)
Similarity:	230/523 - (43%)	Gaps:	71/523 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LASA------FNYFRARRQRSLIKNLKGPFTWPLMGAMHKLLFLTPINFFQRSTEYLTKYG--TF 68
            ||||      ..:.:.:|...||..:.||...||:|..|..:...|....::..|::..|.  ..
  Fly     9 LASALFVGLLLYHLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEFMETYSKDQV 73

  Fly    69 SRCWVFHRLFIPLA---DLELSRQLLE-NDTHLETGYELMKDWLVGGVLMCQSEQWQKRHSLISG 129
            .:.|:...|.:.:.   |:|:....|. ||...|  |:.::.||..|:|:.:..:|.||..:|:.
  Fly    74 LKVWLGPELNVLMGNPKDVEVVLGTLRFNDKAGE--YKALEPWLKEGLLVSRGRKWHKRRKIITP 136

  Fly   130 LFDKGNLEQLIDLSRHQTEQLLQKL----AKQADQKVFDIWYTVSPIVLDLMVMTTCG------A 184
            .|....|:|.:::....:..||:.:    .|..|.. |.::..::...:|.:..|..|      :
  Fly   137 AFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSG-FSLYDWINLCTMDTICETAMGVSINAQS 200

  Fly   185 KPSEEYSKNLKDLSEIYRKRFLSLQSANRFNYWLSSPFMRKRQNRLIKRLNDEHNNLMAMHQSQN 249
            ....||.:.:|.:|.:..||..::.......|.| :|..|..:    |.||       .:||...
  Fly   201 NADSEYVQAVKTISMVLHKRMFNILYRFDLTYML-TPLARAEK----KALN-------VLHQFTE 253

  Fly   250 QLKIENGLDIYQL----------RPIPLKDHKSLLEILLES--KDPQLTGEEICGELNTCNYLGY 302
            ::.::...::.:.          ..:..|...:.|:|||:|  .:..|:..:|..|::|..:.|:
  Fly   254 KIIVQRREELIREGSSQESSNDDADVGAKRKMAFLDILLQSTVDERPLSNLDIREEVDTFMFEGH 318

  Fly   303 QLCSPALCFCLVTIARNPSVQQKCLDELNLAQIKDQGWD-----LEKLNYLDAVLHETMRLYPPQ 362
            ...|.||.|....||.:|..|:||.:|:......|:...     |.:|:|:|..:.||:|:||..
  Fly   319 DTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETLRMYPSV 383

  Fly   363 VIVGRQLKKDFPYTHSIVGDAELPCGSEIYINLYELQRNEVRYPKANHFDAQRFLD--------S 419
            .::||::.:|......::     |.|:.|.|:...|.|.|..:.:.|.|..:|| |        :
  Fly   384 PLLGRKVLEDCEINGKLI-----PAGTNIGISPLYLGRREELFSEPNIFKPERF-DVVTTAEKLN 442

  Fly   420 PPELLSYSLGPRCCPARKFSMQLLKTLLAPILANFEVLPYGDEVR---LDLRLVLGSSNGFQLAL 481
            |...:.:|.|||.|..:||:|..:|.::|.:|.::||...||...   |...|:|.:.......:
  Fly   443 PYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAELILRTKEPLMFKV 507

  Fly   482 KPR 484
            :.|
  Fly   508 RER 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp316a1	NP_648129.2	p450	33..466	CDD:299894	115/476 (24%)
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	118/492 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I1639
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.970