DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp316a1 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_648129.2	Gene:	Cyp316a1 / 38840	FlyBaseID:	FBgn0035790	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	XP_006241152.1	Gene:	Cyp4f39 / 299566	RGDID:	1308796	Length:	550	Species:	Rattus norvegicus

Alignment Length:	524	Identity:	123/524 - (23%)
Similarity:	223/524 - (42%)	Gaps:	64/524 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MILTATFICF-CLASAFNYFR----ARRQRSLIKNLKGPFTWPLMGAMHKLLFLTPINFFQRSTE 60
            ::|...|:.| .|..||..|.    ..|:.|......|.. | |:|  |..::|......|...:
  Rat    27 LLLFLLFLLFRLLLQAFKLFSDFRITCRRLSCFPEPPGRH-W-LLG--HMSMYLPNEKGLQNEKK 87

  Fly    61 YLTKYGTFSRCWVFHRLFIPL----------ADLELSRQLLENDTHLETGYELMKDWLVGGVLMC 115
            .|.........||  ..|:||          ..|..|..:...|   |..|..:|.||..|:|:.
  Rat    88 VLDTMHHIILAWV--GPFLPLLVLVHPDYIKPVLGASAAIAPKD---EFFYSFLKPWLGDGLLIS 147

  Fly   116 QSEQWQKRHSLISGLFDKGNLEQLIDLSRHQTEQLLQKLAKQ-ADQKV--FDIWYTVSPIVLDLM 177
            :..:|.:...|::..|....|:..:.:.......:..|..:. |:..|  ||::..||.:.||.:
  Rat   148 KGNKWSRHRRLLTPAFHFDILKPYMKIFNQSVNIMHAKWRRHLAEGSVTSFDMFEHVSLMTLDSL 212

  Fly   178 ------VMTTCGAKPSEEYSKNLKDLSEIYRKRFLSLQSANRFNYWLSSPFMRKRQNRLIKRLND 236
                  ..:.|..|.| :|..::.:||.:..:|...|.....|.|:|::...|.||     ..:.
  Rat   213 QKCVFSYSSDCQEKLS-DYISSIIELSALVVRRQYRLHHYLDFIYYLTADGRRFRQ-----ACDT 271

  Fly   237 EHNNLMAMHQSQNQLKIENGLDIYQLRPIPLKDHKSL--LEILLESKD---PQLTGEEICGELNT 296
            .||....:.|.:.:...|.|.:.:    :..|..|:|  :::||.:||   .:|:.|:|..|.:|
  Rat   272 VHNFTTEVIQQRRRALRELGAEAW----LKAKQGKTLDFIDVLLLAKDEEGKELSDEDIRAEADT 332

  Fly   297 CNYLGYQLCSPALCFCLVTIARNPSVQQKCLDELNLA----QIKDQGW-DLEKLNYLDAVLHETM 356
            ..:.|:...|..|.:.|..:|:.|..|.||.:|:...    ::::..| ||.:|.:....:.|::
  Rat   333 FMFEGHDTTSSGLSWALFNLAKYPEYQDKCREEIQEVMKGRELEELDWDDLTQLPFTTMCIKESL 397

  Fly   357 RLYPPQVIVGRQLKKDFPYTHSIVGDAELPCGSEIYINLYELQRNEVRYPKANHFDAQRF----- 416
            |.:||..::.|:..:|.......:    :|.|....:::|....|.:.:|.:..::..||
  Rat   398 RQFPPVTLISRRCTEDIKLPDGRI----IPKGIICLVSIYGTHYNPLVWPDSKVYNPYRFDPDIP 458

  Fly   417 -LDSPPELLSYSLGPRCCPARKFSMQLLKTLLAPILANFEV-LPYGDEVRLDLRLVLGSSNGFQL 479
             ..||...:.:|.|||.|..:.|:|..::.::|..|..|.: :....:||....|:|.:.||..|
  Rat   459 QQRSPLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLLRFRLSVDRTRKVRRKPELILRTENGLWL 523

  Fly   480 ALKP 483
            .::|
  Rat   524 NVEP 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp316a1	NP_648129.2	p450	33..466	CDD:299894	108/468 (23%)
Cyp4f39	XP_006241152.1	CYP4F	82..523	CDD:410772	106/459 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910