DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp316a1 and CYP4X1

DIOPT Version :9

Sequence 1:	NP_648129.2	Gene:	Cyp316a1 / 38840	FlyBaseID:	FBgn0035790	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_828847.1	Gene:	CYP4X1 / 260293	HGNCID:	20244	Length:	509	Species:	Homo sapiens

Alignment Length:	511	Identity:	123/511 - (24%)
Similarity:	216/511 - (42%)	Gaps:	64/511 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FCLA----SAFNYFRARRQRSLIKNLKGPFTWPLMGAMHKLL----FLTPINFFQRSTEYLTKYG 66
            ||||    .|...: .|||| |:::|: ||..|   ..|..|    |:...| .::..|.:.||.
Human    20 FCLALGLLQAIKLY-LRRQR-LLRDLR-PFPAP---PTHWFLGHQKFIQDDN-MEKLEEIIEKYP 77

  Fly    67 TFSRCWV--FHRLFIPLADLELSRQLLENDTHLETGYELMKDWLVG-GVLMCQSEQWQKRHSLIS 128
            .....|:  |...|. :.|.:.::.||..........:.....|:| |:......:|.:...|::
Human    78 RAFPFWIGPFQAFFC-IYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLT 141

  Fly   129 GLFDKGNLEQLIDLSRHQTEQLL---QKLAKQADQKVFDIWYTVSPIVLDLMVM------TTCGA 184
            ..|....|:..|::..|..:.:|   :|:....|..| :::..::.:.||:::.      |.|..
Human   142 PGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSV-EVYEHINSMSLDIIMKCAFSKETNCQT 205

  Fly   185 KPSEE-YSKNLKDLSEIYRKRFLSLQSANRFNYWLSSPFMRKRQNRLIKRLNDEHNNLMAMHQSQ 248
            ..:.: |:|.:.:||:|...|..||...:...:.||.  ...|..:|.:.||...:.::...:..
Human   206 NSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSP--QGYRFQKLSRVLNQYTDTIIQERKKS 268

  Fly   249 NQ--LKIENGLDIYQLRPIPLKDHKSLLEILLESKD---PQLTGEEICGELNTCNYLGYQLCSPA 308
            .|  :|.:|         .|.:.::..|:|:|.:||   ...:..::..|::|....|:...:.:
Human   269 LQAGVKQDN---------TPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAAS 324

  Fly   309 LCFCLVTIARNPSVQQKCLDELN--LAQIKDQGWD-LEKLNYLDAVLHETMRLYPPQVIVGRQLK 370
            :.:.|..:|.||..|::|.:|:.  |.......|| |.:::|....:.||.||.|....:.|.|.
Human   325 ISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLS 389

  Fly   371 KDFPYTHSIVGDAELPCGSEIYINLYELQRNEVRYPKANHFDAQRFLDS------PPELLSYSLG 429
            |...:...    ..||.|..:.::::.|..|...:.....||..||...      |...|.:|.|
Human   390 KPLTFPDG----CTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAG 450

  Fly   430 PRCCPARKFSMQLLKTLLAPILANFEVLPYGDEVR---LDLRLVLGSSNGFQLALK 482
            .|.|..::|:|..||..:|.||.:|.|.|  |..|   .....:|...||..|.||
Human   451 SRNCIGQEFAMIELKVTIALILLHFRVTP--DPTRPLTFPNHFILKPKNGMYLHLK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp316a1	NP_648129.2	p450	33..466	CDD:299894	106/466 (23%)
CYP4X1	NP_828847.1	p450	47..501	CDD:306555	107/476 (22%)
CYP4X1	NP_828847.1	heme binding region	447..460		4/12 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920