DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp316a1 and Cyp4x1

DIOPT Version :9

Sequence 1:	NP_648129.2	Gene:	Cyp316a1 / 38840	FlyBaseID:	FBgn0035790	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_663708.1	Gene:	Cyp4x1 / 246767	RGDID:	628719	Length:	507	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	131/530 - (24%)
Similarity:	221/530 - (41%)	Gaps:	100/530 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ICFCLA----SAFNYFRARRQRSLIKNLKGPFTWPLMGAMHKLL----FLTPINFFQRSTEYLTK 64
            :.||||    .|...: .|||| |:::|: ||..|   ..|.||    ||...| .::..|.:.:
  Rat    18 LVFCLALVLMQAVKLY-LRRQR-LLRDLR-PFPGP---TAHWLLGHQKFLQEDN-MEKLDEIVKE 75

  Fly    65 YGTFSRCWV-----FHRLFIP-LADLELSRQLLENDTHLETGYELMKDWLVGGVLMCQSEQWQKR 123
            |.....|||     |..::.| .|.:.|||    .|...:..::||..:|..|:|.....:|.:.
  Rat    76 YPCAFPCWVGPFQAFFYIYDPDYAKIFLSR----TDPKTQYLHQLMTPFLGRGLLNLDGPRWFQH 136

  Fly   124 HSLISGLFDKGNLEQLIDLSRHQTEQLLQKLAK--QADQKVFDIWYTVSPIVLDLMVMTTCGAKP 186
            ..|::..|.:..|:..:|:..|....:|.|..|  ...:...:::..::.:.||:::....|.:.
  Rat   137 RCLLTPAFHQDILKPCVDMMAHSVNMMLDKWEKTWTTQETTIEVFEHINLMTLDIIMKCAFGQET 201

  Fly   187 S-------EEYSKNLKDLSEIYRKRFLSLQSANRFNYWLSSPFMRKRQNRLIKRLNDEHNNLM-- 242
            :       |.|.|...:|.||...|.        :|:|        ..:.:|.:|:.:.:...
  Rat   202 NCQINGTYESYVKATFELGEIISSRL--------YNFW--------HHHDIIFKLSPKGHCFQEL 250

  Fly   243 --AMHQSQNQLKIENGLDIYQLRPIPLKDH---------KSLLEILLESK---DPQLTGEEICGE 293
              .:||...:        |.|.|...|||.         ::.|:|:|.::   :...:..::..|
  Rat   251 GKVIHQCTEK--------IIQDRKKTLKDQVNQDDTQTSQNFLDIVLSAQAGDEKAFSDADLRSE 307

  Fly   294 LNTCNYLGYQLCSPALCFCLVTIARNPSVQQKCLDELNLAQIKDQG----WD-LEKLNYLDAVLH 353
            :||..:.|:...:.::.:.|..:|.||..|.:|..|:.  .|...|    |: |:::.|....:.
  Rat   308 VNTFMWAGHDASAASISWLLYCLALNPEHQDRCRTEIR--SILGDGSSITWEQLDEIPYTTMCIK 370

  Fly   354 ETMRLYPPQVIVGRQLKK--DFPYTHSIVGDAELPCGSEIYINLYELQRNEVRYPKANHFDAQRF 416
            ||:||.||...:.|:|.|  ..|..||      ||.|..:.::::.|..|...:.....||..||
  Rat   371 ETLRLIPPIPSISRELSKPLTLPDGHS------LPAGMTVVLSIWGLHHNPAVWKDPKVFDPLRF 429

  Fly   417 LDS------PPELLSYSLGPRCCPARKFSMQLLKTLLAPILANFEVLPYGDEVR---LDLRLVLG 472
            ...      |...|.:|.|||.|..::|:|..||..:|..|..|.|.  .|..|   .....||.
  Rat   430 TKENSEQRHPCAFLPFSSGPRNCIGQQFAMLELKVAIALTLLRFRVA--ADLTRPPAFSSHTVLR 492

  Fly   473 SSNGFQLALK 482
            ..:|..|.||
  Rat   493 PKHGIYLHLK 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp316a1	NP_648129.2	p450	33..466	CDD:299894	114/483 (24%)
Cyp4x1	NP_663708.1	CYP4B-like	66..500	CDD:410771	108/471 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010