DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp316a1 and CYP4Z1

DIOPT Version :9

Sequence 1:	NP_648129.2	Gene:	Cyp316a1 / 38840	FlyBaseID:	FBgn0035790	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_835235.1	Gene:	CYP4Z1 / 199974	HGNCID:	20583	Length:	505	Species:	Homo sapiens

Alignment Length:	522	Identity:	120/522 - (22%)
Similarity:	212/522 - (40%)	Gaps:	76/522 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LTATFICFCLASAFNYFRA-RRQRSLIKNL----KGPFTWPLMGAMHKLLFLTPINFFQRSTEYL 62
            |....:|..|. .|...|. :|:|.:|:.|    ..|..| ..|  ||..:  |:..|:...:.:
Human    15 LLLILLCMSLL-LFQVIRLYQRRRWMIRALHLFPAPPAHW-FYG--HKEFY--PVKEFEVYHKLM 73

  Fly    63 TKYGTFSRCWVF-HRLFIPLADLELSRQLLE-NDTHLETGYELMKDWLVGGVLMCQSEQWQKRHS 125
            .||......||. ..:|..:.|.:.::.||: .|......:::::.|:..|::.....:|:|...
Human    74 EKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILESWVGRGLVTLDGSKWKKHRQ 138

  Fly   126 LISGLFDKGNLEQLIDLSRHQTEQLLQKLAKQ-ADQKVFDIWYTVSPIVLDLMVMTTCGAKPSEE 189
            ::...|:...|:..|.:.......:|.|..:. |.....:::..||.:.||.::  .|..  |.:
Human   139 IVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIM--KCAF--SHQ 199

  Fly   190 YSKNLKDLSEIYRKRFLSLQSANRFNYWLSSPFMRKRQNRLIKRLNDEHNNLMAMHQSQNQLKIE 254
            .|..|....:.|.|...:|           |....:|.|..:     .||:|:....||.|:..:
Human   200 GSIQLDSTLDSYLKAVFNL-----------SKISNQRMNNFL-----HHNDLVFKFSSQGQIFSK 248

  Fly   255 NGLDIYQLRPIPLKDHK-----------------SLLEILLESKD---PQLTGEEICGELNTCNY 299
            ...:::|.....::|.|                 ..|:|||.:|.   ...:..::..|:.|..:
Human   249 FNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMF 313

  Fly   300 LGYQLCSPALCFCLVTIARNPSVQQKCLDELNLAQIKDQG----WD-LEKLNYLDAVLHETMRLY 359
            .|:...|.|:.:.|..:|:.|..||:|.||:.  ::...|    |: |.::.|....:.|.:|||
Human   314 AGHDTTSSAISWILYCLAKYPEHQQRCRDEIR--ELLGDGSSITWEHLSQMPYTTMCIKECLRLY 376

  Fly   360 PPQVIVGRQLKK--DFPYTHSIVGDAELPCGSEIYINLYELQRNEVRYPKANHFDAQRFLDS--- 419
            .|.|.:.|.|.|  .||...|      ||.|..::||::.|..|...:.....|:..||...
Human   377 APVVNISRLLDKPITFPDGRS------LPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSE 435

  Fly   420 ---PPELLSYSLGPRCCPARKFSMQLLKTLLAPILANFEVLPYGDEVRLDLR-LVLGSSNGFQLA 480
               |...:.:|.|.|.|..:.|::...|..:|..|..|::.|........:| :||.|.||..:.
Human   436 KIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRPPQPVRQVVLKSKNGIHVF 500

  Fly   481 LK 482
            .|
Human   501 AK 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp316a1	NP_648129.2	p450	33..466	CDD:299894	104/468 (22%)
CYP4Z1	NP_835235.1	p450	47..500	CDD:278495	110/485 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910