DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp316a1 and Cyp4a14

DIOPT Version :9

Sequence 1:	NP_648129.2	Gene:	Cyp316a1 / 38840	FlyBaseID:	FBgn0035790	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_031848.1	Gene:	Cyp4a14 / 13119	MGIID:	1096550	Length:	507	Species:	Mus musculus

Alignment Length:	524	Identity:	130/524 - (24%)
Similarity:	222/524 - (42%)	Gaps:	100/524 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 IKNLKGPFTWPLMGAMHKLLFLTPINFFQRSTEYLTKYGTFSRC------WVFHRLFIPLADLEL 86
            :..:.|.|.|..:.::..:|| ..:.|:.| .::|.|......|      |..|     |.|.||
Mouse    12 LDGISGFFQWAFLLSLFLVLF-KAVQFYLR-RQWLLKTLQHFPCMPSHWLWGHH-----LKDKEL 69

  Fly    87 SRQLL---------------------------------ENDTHLETGYELMKDWLVGGVLMCQSE 118
            .:.|:                                 .:|......|:....|:..|:|:...:
Mouse    70 QQILIWVEKFPSACLQCLSGSNIRVLLYDPDYVKVVLGRSDPKASGIYQFFAPWIGYGLLLLNGK 134

  Fly   119 QWQKRHSLISGLFDKGNLEQLIDLSRHQTEQLLQKLAK-QADQKVFDIWYTVSPIVLDLMVMTTC 182
            :|.:...:::..|....|:..:.:.......:|.|..| .......:|::.||.:.||.::....
Mouse   135 KWFQHRRMLTPAFHYDILKPYVKIMADSVNIMLDKWEKLDGQDHPLEIFHCVSLMTLDTVMKCAF 199

  Fly   183 GAKPSEE-------YSKNLKDLSEIYRKRFLSLQSA-NRFN--YWLSSPFMRKRQNRLIKRLNDE 237
            ..:.|.:       |:|.::||:.:   .|..|::| .::|  |.:||.   .|.:....::..|
Mouse   200 SYQGSVQLDENSKLYTKAVEDLNNL---TFFRLRNAFYKYNIIYNMSSD---GRLSHHACQIAHE 258

  Fly   238 H-NNLMAMHQSQNQLKIENGLDIYQLRPIPLKDHKSLLEILL----ESKDPQLTGEEICGELNTC 297
            | :.::.|.:||    ::|..::.:.|.   |.|...|:|||    |.:: .|:.|::..|::|.
Mouse   259 HTDGVIKMRKSQ----LQNEEELQKARK---KRHLDFLDILLFARMEDRN-SLSDEDLRAEVDTF 315

  Fly   298 NYLGYQLCSPALCFCLVTIARNPSVQQKCLDELNLAQIKDQG----WD-LEKLNYLDAVLHETMR 357
            .:.|:...:..:.:....:|.:|..||:|.:|:.  .|...|    || |.::.|....:.|.:|
Mouse   316 MFEGHDTTASGISWIFYALATHPEHQQRCREEVQ--SILGDGTSVTWDHLGQMPYTTMCIKEALR 378

  Fly   358 LYPPQVIVGRQLKK--DFPYTHSIVGDAELPCGSEIYINLYELQRNEVRYPKANHFDAQRFL-DS 419
            ||||.:.|.|:|..  .||...||      |.|....|::|.|..|...:|....||..||. ||
Mouse   379 LYPPVISVSRELSSPVTFPDGRSI------PKGITATISIYGLHHNPRFWPNPKVFDPSRFAPDS 437

  Fly   420 PPE---LLSYSLGPRCCPARKFSMQLLKTLLAPILANFEVLPYGDEVRLDL---RLVLGSSNGFQ 478
            ...   .|.:|.|.|.|..::|:|..||..:|..|..||:||  |..|:.:   ||||.|.||..
Mouse   438 SHHSHAYLPFSGGSRNCIGKQFAMNELKVAVALTLLRFELLP--DPTRIPVPIARLVLKSKNGIH 500

  Fly   479 LALK 482
            |.||
Mouse   501 LCLK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp316a1	NP_648129.2	p450	33..466	CDD:299894	120/498 (24%)
Cyp4a14	NP_031848.1	p450	52..501	CDD:278495	118/477 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820