DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp316a1 and cyp4f3

DIOPT Version :9

Sequence 1:	NP_648129.2	Gene:	Cyp316a1 / 38840	FlyBaseID:	FBgn0035790	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_001083010.1	Gene:	cyp4f3 / 100037390	ZFINID:	ZDB-GENE-070410-108	Length:	511	Species:	Danio rerio

Alignment Length:	475	Identity:	122/475 - (25%)
Similarity:	201/475 - (42%)	Gaps:	82/475 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 QRSTEYLTKYGTFSRCWV---FH---RLFIPLADLELSRQLLENDTHL----ETGYELMKDWLVG 110
            ||..:.:.||| .|..|.   |:   |||.|    :..|.||.....:    ...|..||.|| |
Zfish    60 QRVDDLVCKYG-HSCSWFLGPFYNMVRLFHP----DYIRSLLTASASITLKDRIFYGFMKPWL-G 118

  Fly   111 GVLMCQS-EQWQKRHSLISGLFDKGNLEQLIDLSRHQTEQL---LQKLAKQADQKVFDIWYTVSP 171
            ..|:.|| ::|.:...|::..|....|::.:.:....|..:   .::|..:.:..| |::..:|.
Zfish   119 NCLLLQSGQEWSRHRRLLTPAFHFDILKKYVHIFNQSTNIMHDEWRRLLAKGEHSV-DMFEQISS 182

  Fly   172 IVLDLMVMTT--CGAKPSE---EYSKNLKDLSEIYRKRFLSLQSANRFNYWLSSPFMRKRQNRLI 231
            :.||.::..|  |.....|   :|...:.|||.:..:|...|.....:.||.|:...|.:|...:
Zfish   183 LTLDSLLKCTFSCDTHSQEKPRQYISAILDLSRLLVQRQHYLPYHWDWLYWRSAQGRRFQQACAV 247

  Fly   232 KRLNDEHNNLMAMHQSQNQLKIENGLDIYQLRPIPL------------------KDHKSLLEILL 278
                        :||..        .||.|.|...|                  :.:..|:::||
Zfish   248 ------------VHQFT--------ADIVQERRTQLDQQSDPESHPENTGRYRKRKNTDLIDLLL 292

  Fly   279 ESKDPQ---LTGEEICGELNTCNYLGYQLCSPALCFCLVTIARNPSVQQKCLDEL-NLAQIKDQ- 338
            .:||.:   ||.|||....:...:.|:...:.||.:....:|.|...|::|..|: :|...:|.
Zfish   293 LAKDDKGEGLTNEEIKAHADMFMFAGHDTTASALSWIFYNLAMNQDYQERCRAEVRDLLADRDTH 357

  Fly   339 --GW-DLEKLNYLDAVLHETMRLYPPQVIVGRQLKKDFPYTHSIVGDAELPCGSEIYINLYELQR 400
              || ||.:|.:....:.|::||:.|.:.:.|...::.    ...||..:|.|....|::|.:.|
Zfish   358 TIGWEDLSQLTFTTMCIKESLRLHSPVLALTRYYSQNM----KTPGDCVIPHGCLCLISIYGVHR 418

  Fly   401 NEVRYPKANHFDAQRF------LDSPPELLSYSLGPRCCPARKFSMQLLKTLLAPILANFEVLPY 459
            |...:|....||..||      ..||...:.:|.|||.|..:.|:|..:|.::|..||.|::||.
Zfish   419 NPQVWPDPLVFDPTRFDPHNSDSRSPHAFIPFSAGPRNCIGQNFAMAEMKVVVALTLARFKILPG 483

  Fly   460 GDEVRLDLRLVLGSSNGFQL 479
            ...||...:|||.:..|..|
Zfish   484 PKPVRRLYQLVLRAEGGMIL 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp316a1	NP_648129.2	p450	33..466	CDD:299894	117/460 (25%)
cyp4f3	NP_001083010.1	p450	38..503	CDD:278495	121/473 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010