DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mthl6 and Adgrl2

DIOPT Version :9

Sequence 1:NP_788473.1 Gene:mthl6 / 38839 FlyBaseID:FBgn0035789 Length:480 Species:Drosophila melanogaster
Sequence 2:XP_036019331.1 Gene:Adgrl2 / 99633 MGIID:2139714 Length:1494 Species:Mus musculus


Alignment Length:390 Identity:78/390 - (20%)
Similarity:147/390 - (37%) Gaps:82/390 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 EELIIPAHLTGLYTFRQLADGSQEPVKSHLRACICKLKPCI-----RFCCPRNKMMPNSRCSDGL 105
            ::...|..|.||.:..||   |...||.:.|..:.||...|     :|....|..:.......|.
Mouse   687 QDFKFPLGLKGLGSSIQL---SANTVKQNSRNGLAKLVFIIYRSLGQFLSTENATIKLGADLMGR 748

  Fly   106 TENLKRINPYLKITLEDGTIGKYYLLTDMIVLRYEFRYCEKVVSVQEDQYKLYENGSFMIKPDVN 170
            ...:...:|.:.:::...:...|  |||.::.        .:..:..|.| ...|.||       
Mouse   749 NSTIAVNSPVISVSINKESSRVY--LTDPVLF--------TLPHIDPDNY-FNANCSF------- 795

  Fly   171 WTLSKQ-----WYCLHPRLEDPNS-------------IWILEHVYIPKS-------MPAVPQVG- 209
            |..|::     |.....:|.|.|.             ..::.|..|...       :..:..|| 
Mouse   796 WNYSERTMMGYWSTQGCKLVDTNKTRTTCACSHLTNFAILMAHREIAYKDGVHHLLLTVITWVGI 860

  Fly   210 TISMVG---CILTIAVYLYIKKLRNLLGKCFICYVFCKFVQYLIWAGGDLNLWNNICSL-AGYTN 270
            .:|:|.   ||.|...:..::..||.:.|.....:|  ..:::...|.|...:...|.: ||..:
Mouse   861 VVSLVCLAICIFTFCFFRGLQSDRNTIHKNLCINLF--IAEFIFLIGIDKTKYTIACPVFAGLLH 923

  Fly   271 YFFALASHFWLSVMSHQIWKNLRLINRDERSY-HFLIYNIYGWGTPAIMTAITYLVDWAWEDRPD 334
            :|| ||:..|:.:...|::  |.|:...|..| ....|.:.|:..||.:..::..:|:       
Mouse   924 FFF-LAAFSWMCLEGVQLY--LMLVEVFESEYSRKKYYYVAGYLFPATVVGVSAAIDY------- 978

  Fly   335 KLNWIPGVG-LYRCWI---NTYDWSAMIYLYGPMLILSLFNVVTFILTVNHIMKIKSSVKSSTQQ 395
                 ...| :..||:   |.:.||    ..||:..:.|.|::..::|:..::|..:::|..:.:
Mouse   979 -----KSYGTVQACWLHVDNYFIWS----FIGPVTFIILLNIIFLVITLCKMVKHSNTLKPDSSR 1034

  Fly   396  395
            Mouse  1035  1034

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl6NP_788473.1 Mth_Ecto 25..197 CDD:119403 33/173 (19%)
7tm_4 211..398 CDD:304433 42/194 (22%)
Adgrl2XP_036019331.1 Gal_Lectin 49..129 CDD:396628
OLF 143..399 CDD:413369
HormR 470..534 CDD:214468
GAIN 543..765 CDD:406802 17/80 (21%)
GPS 789..841 CDD:197639 10/58 (17%)
7tm_GPCRs 850..1130 CDD:421689 44/206 (21%)
TM helix 1 851..876 CDD:410628 7/24 (29%)
TM helix 2 885..907 CDD:410628 4/23 (17%)
TM helix 3 916..943 CDD:410628 8/29 (28%)
TM helix 4 955..975 CDD:410628 4/19 (21%)
TM helix 5 992..1021 CDD:410628 8/32 (25%)
TM helix 6 1037..1088 CDD:410628
TM helix 7 1092..1117 CDD:410628
Latrophilin 1129..1494 CDD:396778
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.