Protein Alignment mthl6 and ADGRG7

DIOPT Version :9

• Sequence 1: NP_788473.1
• Gene: mthl6 / 38839
• FlyBaseID: FBgn0035789
• Length: 480
• Species: Drosophila melanogaster
• Sequence 2: NP_116176.2
• Gene: ADGRG7 / 84873
• HGNCID: 19241
• Length: 797
• Species: Homo sapiens
• Alignment Length: 446
• Identity: 92/446 - (20%)
• Similarity: 176/446 - (39%)
• Gaps: 148/446 - (33%)

  Fly   143 YCEKVVSVQEDQYKLYENGS--FMIKPDVN-------------WTLS-KQW--Y-C--------- 179
            :.:|::|.:.|:.:..::.|  .:..|..|             |.|| |.|  | |
Human   343 FSQKIISSKTDENEQDQSASVDMVFSPKYNQKEFQLYSYACVYWNLSAKDWDTYGCQKDKGTDGF 407

  Fly   180 LHPRLEDPNSIWIL-----EHVYIPKSMPAVPQVG-TISMVGCILTIAVYLYIKKLRN------L 232
            |..|.....:..:|     ::.| |||:..:..|| .:|:.|..||:...:..:|:|.      |
Human   408 LRCRCNHTTNFAVLMTFKKDYQY-PKSLDILSNVGCALSVTGLALTVIFQIVTRKVRKTSVTWVL 471

  Fly   233 LGKCFICYVF-CKFV-------QYLIWAGGD----------------LNLWNNICSLAGYTNYFF 273
            :..|....:| ..||       :.|..:.||                :|:.|.:|:......::|
Human   472 VNLCISMLIFNLLFVFGIENSNKNLQTSDGDINNIDFDNNDIPRTDTINIPNPMCTAIAALLHYF 536

  Fly   274 ALASHFWLSVMSHQIW----KNLRLINRDERSYHFLIY-NIYGWGTPAIMTAITYLV-------- 325
            .|.:..|.::.:.|::    :.::.:.|     ||::: ::.|||.|||:.|||..|
Human   537 LLVTFTWNALSAAQLYYLLIRTMKPLPR-----HFILFISLIGWGVPAIVVAITVGVIYSQNGNN 596

  Fly   326 -DWAWEDRPDKLNWIPGVGLYRCWINTYD----------WSAMIYLYGPMLILSLFNVVTFI-LT 378
             .|..:.|.:|:          ||:...:          ||.::    |:.|:.:.|||.|| ::
Human   597 PQWELDYRQEKI----------CWLAIPEPNGVIKSPLLWSFIV----PVTIILISNVVMFITIS 647

  Fly   379 VNHIMKIKSSVKSSTQQQRKCIQNNDFLLYLRLSVMMGVTGISEVITYFVKRHKFWRQVLRVPN- 442
            :..:.|...::.|:    :|.......:..|.::|:.|:|.|   :.|           |.:.|
Human   648 IKVLWKNNQNLTST----KKVSSMKKIVSTLSVAVVFGITWI---LAY-----------LMLVND 694

  Fly   443 ------------FFHLGSGIVVFVLFILKRSTFQ-------MIMERISGPRRQQPA 479
                        .|:...|:.:|:|:.::...||       |::..| |.|:..|:
Human   695 DSIRIVFSYIFCLFNTTQGLQIFILYTVRTKVFQSEASKVLMLLSSI-GRRKSLPS 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl6	NP_788473.1	Mth_Ecto	25..197	CDD:119403	16/86 (19%)
		7tm_4	211..398	CDD:304433	50/241 (21%)
ADGRG7	NP_116176.2	GPS	383..422	CDD:197639	9/38 (24%)
		7tmB2_GPR128	431..737	CDD:320385	70/342 (20%)
		TM helix 1	433..458	CDD:320385	7/24 (29%)
		TM helix 2	468..490	CDD:320385	5/21 (24%)
		TM helix 3	527..554	CDD:320385	4/26 (15%)
		TM helix 4	567..587	CDD:320385	9/19 (47%)
		TM helix 5	621..651	CDD:320385	9/33 (27%)
		TM helix 6	665..692	CDD:320385	7/40 (18%)
		TM helix 7	699..724	CDD:320385	4/24 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810