DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl6 and adgrg4a

DIOPT Version :9

Sequence 1:	NP_788473.1	Gene:	mthl6 / 38839	FlyBaseID:	FBgn0035789	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	XP_021336868.1	Gene:	adgrg4a / 793963	ZFINID:	ZDB-GENE-121129-2	Length:	1201	Species:	Danio rerio

Alignment Length:	272	Identity:	57/272 - (20%)
Similarity:	105/272 - (38%)	Gaps:	84/272 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 DPNSIWILEHVYIPKSMPAVPQVGTISMVGCIL-------TIAVYLYIKKLRN------------ 231
            :|...|:|.               .||.|||.:       |:..||..:|||.
Zfish   867 NPKDEWVLT---------------IISYVGCGISSIFLGVTLLTYLAFEKLRRDYPSKILINLCM 916

  Fly   232 -LLGKCFICYVFCKFVQYLIWAGGDLNLW------NNIC-SLAGYTNYFFALASHFWLSVMSHQI 288
             |||...:..|               |.|      |.:| ::|.:.:||| ||:..|:.:.:..:
Zfish   917 ALLGLNMLFLV---------------NSWFASFNSNALCITVAAFQHYFF-LATFTWMGLGAINM 965

  Fly   289 WKNL-RLINRDERSYHFLIYNIYGWGTPAIMTAITYLVDWAWEDRPDKLNWIPGVGLYR-----C 347
            :..| ::.|....|| .|.:...|||.|..:..:...:|:      :.........|.:     |
Zfish   966 YLALVKVFNSYVPSY-ILKFCAVGWGIPLSVVILVLAIDF------NSYGTSLSTDLLQESTAFC 1023

  Fly   348 WINTYDWSAMIYLYGPMLILSLFNVVTFILTVNHIMKIKSSVKSSTQQQRKCIQNNDFLLYLR-- 410
            |... |.:..:.:....:::.:.|::.|::.:..|.|::.:..||:::        .||..||
Zfish  1024 WFKN-DVTFYVTVVSFAILIMVCNIIVFVVVLVQIHKMRVNKPSSSRK--------GFLHDLRVV 1079

  Fly   411 --LSVMMGVTGI 420
              |:.::|:|.|
Zfish  1080 ASLTFLLGLTWI 1091

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl6	NP_788473.1	Mth_Ecto	25..197	CDD:119403	3/10 (30%)
mthl6	NP_788473.1	7tm_4	211..398	CDD:304433	46/219 (21%)
adgrg4a	XP_021336868.1	LamG	50..210	CDD:328935
		HsdR	<637..>729	CDD:333053
		GPS	815..858	CDD:307782
		7tmB2_GPR112	871..1138	CDD:320663	56/268 (21%)
		TM helix 1	873..898	CDD:320663	8/39 (21%)
		TM helix 2	908..930	CDD:320663	5/36 (14%)
		TM helix 3	941..968	CDD:320663	7/27 (26%)
		TM helix 4	983..999	CDD:320663	4/15 (27%)
		TM helix 5	1028..1051	CDD:320663	2/22 (9%)
		TM helix 6	1073..1098	CDD:320663	7/19 (37%)
		TM helix 7	1102..1127	CDD:320663
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910