Protein Alignment mthl6 and VIPR1

DIOPT Version :10

• Sequence 1: NP_788473.1
• Gene: mthl6 / 38839
• FlyBaseID: FBgn0035789
• Length: 480
• Species: Drosophila melanogaster
• Sequence 2: NP_004615.2
• Gene: VIPR1 / 7433
• HGNCID: 12694
• Length: 457
• Species: Homo sapiens
• Alignment Length: 496
• Identity: 102/496 - (20%)
• Similarity: 174/496 - (35%)
• Gaps: 135/496 - (27%)

  Fly     3 LNILAIILVFVI---SSQSEAVIPGCDYFDTVDISHIPKLNDSYAYEELIIPAHLTGLYTFRQLA 64
            |.:||..|.:.:   ..|:..:...|||...:::.|...|.::....|.|..:.:....|.....
Human    12 LCVLAGALAWALGPAGGQAARLQEECDYVQMIEVQHKQCLEEAQLENETIGCSKMWDNLTCWPAT 76

  Fly    65 DGSQEPVKSHLRAC--ICKLKPCIRFCCPRNKMMPNSRCSDGLTENLKRINPYLKITLEDGTIGK 127
            ...|..|    .||  |.||...|:   .||   .:..|:|   |....:.|           |.
Human    77 PRGQVVV----LACPLIFKLFSSIQ---GRN---VSRSCTD---EGWTHLEP-----------GP 117

  Fly   128 YYLLTDMIVLRYEFRYCEKVVSVQEDQYKLYENGSFMIKPDVNWTLSKQWYCLHPRLEDPNSIWI 192
            |.:...:         .:|..|:.|.|...|  ||......:.:.||
Human   118 YPIACGL---------DDKAASLDEQQTMFY--GSVKTGYTIGYGLS------------------ 153

  Fly   193 LEHVYIPKSMPAVPQVGTISMVGCILTIAVYLYIKKLRNLLGKCFICYVFCK-FVQYLIWAGG-- 254
                           :.|:.:...||::     .:||.     |...|:... |:.:::.|..
Human   154 ---------------LATLLVATAILSL-----FRKLH-----CTRNYIHMHLFISFILRAAAVF 193

  Fly   255 --DLNLWNN-----------ICSLAGYTNYFFALASHFWLSVMSHQIWKNLRLINRDERSYHFLI 306
              ||.|:::           .|..|.....:..:|:.|||.|....::..|.:....||.| |..
Human   194 IKDLALFDSGESDQCSEGSVGCKAAMVFFQYCVMANFFWLLVEGLYLYTLLAVSFFSERKY-FWG 257

  Fly   307 YNIYGWGTPAIMTAITYLVDWAWEDRPDKLNWIPGVGLYRCWINTYDWSAMIYLYGPMLILSLFN 371
            |.:.|||.|:..|.:..:....:||             |.|| :|.:.|....:.||:|...|.|
Human   258 YILIGWGVPSTFTMVWTIARIHFED-------------YGCW-DTINSSLWWIIKGPILTSILVN 308

  Fly   372 VVTFILTVNHIMKIKSSVKSSTQQQRKCIQNNDFLLYLRLS----VMMGVTGISEVITYFVKRHK 432
            .:.||..:..:::         :.:...|:.:|...|.||:    :::.:.|:..::..|.. ..
Human   309 FILFICIIRILLQ---------KLRPPDIRKSDSSPYSRLARSTLLLIPLFGVHYIMFAFFP-DN 363

  Fly   433 FWRQVLRVPNFFHL--GS--GIVVFVLFILKRSTFQMIMER 469
            |..:|..|   |.|  ||  |.||.:|:.......|..:.|
Human   364 FKPEVKMV---FELVVGSFQGFVVAILYCFLNGEVQAELRR 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl6	NP_788473.1	Methuselah_N	25..195	CDD:429053	33/171 (19%)
		7tmB3_Methuselah-like	211..471	CDD:410632	63/283 (22%)
		TM helix 2	234..256	CDD:410632	4/26 (15%)
		TM helix 3	264..291	CDD:410632	6/26 (23%)
		TM helix 4	304..324	CDD:410632	7/19 (37%)
		TM helix 5	353..382	CDD:410632	8/28 (29%)
		TM helix 6	400..427	CDD:410632	6/30 (20%)
		TM helix 7	435..460	CDD:410632	10/28 (36%)
VIPR1	NP_004615.2	HormR	59..128	CDD:214468	19/101 (19%)
		7tm_GPCRs	139..405	CDD:475119	69/336 (21%)
		TM helix 1	142..166	CDD:410628	5/56 (9%)
		TM helix 2	175..196	CDD:410628	3/20 (15%)
		TM helix 3	216..238	CDD:410628	6/21 (29%)
		TM helix 4	257..273	CDD:410628	6/15 (40%)
		TM helix 5	291..313	CDD:410628	6/21 (29%)
		TM helix 6	340..362	CDD:410628	2/22 (9%)
		TM helix 7	367..392	CDD:410628	10/27 (37%)