DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl6 and adgrf7

DIOPT Version :9

Sequence 1:	NP_788473.1	Gene:	mthl6 / 38839	FlyBaseID:	FBgn0035789	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	XP_017208207.1	Gene:	adgrf7 / 613165	ZFINID:	ZDB-GENE-041001-214	Length:	694	Species:	Danio rerio

Alignment Length:	551	Identity:	101/551 - (18%)
Similarity:	182/551 - (33%)	Gaps:	186/551 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ILVFVIS-SQ----SEAVIPGCDYFDTVDI----------SHIPKLNDSYAYEELI--IPAHLT- 55
            |||.:.| ||    ||:|:.  |:..||||          ..:.|.|.|.:....:  |...||
Zfish   191 ILVIIASVSQNIIISESVME--DFLKTVDILVSNEATASWQSLTKENPSISLLSAVEDISNRLTE 253

  Fly    56 GLYTFRQLADGSQEPV-------KSHLRACICK------LKP---CIRFCCPRNKMMPNSRCSDG 104
            |.:|..|........|       ||:|.....:      |.|   .|......|.::|....::|
Zfish   254 GSFTINQKYIELNRTVINNSYTGKSNLPNSATEILIPQILNPTSLTIIIFTTLNNILPTQDSANG 318

  Fly   105 LTENLKRINPYLKITLEDGTIGKYYLLTDMIVLRYEFRYCEKVVSVQEDQ-------------YK 156
            :.:...|||..|.:...:.|:.....:.|                 ..||             ..
Zfish   319 IVKPDMRINGDLVVVKANQTLHSMSFVFD-----------------TTDQSLGNPQCVFWNFNLS 366

  Fly   157 LYENGSFMIKPDVNWTLSKQWYCLHPR----LEDPNSIWILEHVYIPKSMPAVPQVGTISMVGCI 217
            .:::....:||..|.|......|.|..    |..|.||..:...|             ::.:|..
Zfish   367 AWDSTGCEVKPGRNETGIITCECNHTASFSILMSPFSIDHIAFAY-------------VTYIGVG 418

  Fly   218 LTIAVYLYIKKLRNLLGKCFICYVFCKFVQYLIWAG---GDLNLWNNI----------------- 262
            :::|                 |.:.|..::.::|..   .|.:...::
Zfish   419 ISVA-----------------CLILCLIIEAIVWKAVRRNDTSYMRHVSIVNIAISLLIADVCFI 466

  Fly   263 ----------------CSLAGYTNYFFALASHFWLSVMSHQI-WKNLRLINRDERSYHFLIYNIY 310
                            ||...:..:||.||..||:.:.:..: ::.:.::::..|:...:|..:.
Zfish   467 IGAAILDEEQLTPADRCSSVVFFMHFFYLALFFWMLISALLLFYRVVMVLSQMSRAKMMVISFLL 531

  Fly   311 GWGTPAIMTAITYLVDWAWEDRPDKLNWIPGVGLYRCWINTYDWSAMIYLYGPMLILSLFNVVTF 375
            |:|.|.:::.||.    |....|...     |....||:|..:...::....|.|.:...|:|.|
Zfish   532 GYGAPLLISVITV----ASTVGPQMY-----VSKQACWLNWNESRNLLAFVIPALTIVAINLVVF 587

  Fly   376 ILTVNHIMKIKSSVKSSTQQQRK-------CIQNNDFLLYLRLSVMMGVT---GISEVITYFVKR 430
            |:.:..|.|.::.  ::||...|       |:      .:...::..|:|   ||...::
Zfish   588 IVVLYKIFKRRAG--AATQPDWKNALVVARCV------AFFTPALACGITWGFGIGTTVS----- 639

  Fly   431 HKFWRQVLRVPNFFHLGSGIVVFVLFILKRS 461
                             :|:.|.|:|.|..|
Zfish   640 -----------------AGLFVHVVFALFNS 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl6	NP_788473.1	Mth_Ecto	25..197	CDD:119403	42/217 (19%)
mthl6	NP_788473.1	7tm_4	211..398	CDD:304433	37/223 (17%)
adgrf7	XP_017208207.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910