Protein Alignment mthl6 and ADGRB2

DIOPT Version :10

• Sequence 1: NP_788473.1
• Gene: mthl6 / 38839
• FlyBaseID: FBgn0035789
• Length: 480
• Species: Drosophila melanogaster
• Sequence 2: NP_001351786.1
• Gene: ADGRB2 / 576
• HGNCID: 944
• Length: 1585
• Species: Homo sapiens
• Alignment Length: 332
• Identity: 67/332 - (20%)
• Similarity: 126/332 - (37%)
• Gaps: 100/332 - (30%)

  Fly   199 PKSM-------PAVPQVGTISMVGC------ILT-IAVYL----YIKKLRNLLGKCFICYVFCKF 245
            ||.:       |:||.|     :||      :|| :|:|.    :||..|::     |...||..
Human   921 PKDLTLELAGSPSVPLV-----IGCAVSCMALLTLLAIYAAFWRFIKSERSI-----ILLNFCLS 975

  Fly   246 V---QYLIWAGGDLNLWNNICSLAGYTNYFFALASHFWLSVMSHQIWKN-LRLINRDERSYHFLI 306
            :   ..||..|....|...:|::.....:||.|:|..|:..   :.|:: |.:|.|.........
Human   976 ILASNILILVGQSRVLSKGVCTMTAAFLHFFFLSSFCWVLT---EAWQSYLAVIGRMRTRLVRKR 1037

  Fly   307 YNIYGWGTPAIMTAITYLVDWAWEDRPDKLNWIPGVGLYR---------CWINTYDWSAMIYLY- 361
            :...|||.||::.|::                   ||..|         ||::..  ..::|.:
Human  1038 FLCLGWGLPALVVAVS-------------------VGFTRTKGYGTSSYCWLSLE--GGLLYAFV 1081

  Fly   362 GPMLILSLFNVVTFILTVNHIMKIKSSVKSSTQQQR----KC----------------------- 399
            ||..::.|.|::..|:..|.:| .:..:...:::||    :|
Human  1082 GPAAVIVLVNMLIGIIVFNKLM-ARDGISDKSKKQRAGSERCPWASLLLPCSACGAVPSPLLSSA 1145

  Fly   400 -IQNNDFLLYLRLSV--MMGVTGISEVITYFVKRHKFWRQVLRVPNFFHLGSGIVVFVLFILKRS 461
             .:|....|:....|  ::.:|.:|.|:....:|...::.:..|   |:...|.|:..:....|.
Human  1146 SARNAMASLWSSCVVLPLLALTWMSAVLAMTDRRSVLFQALFAV---FNSAQGFVITAVHCFLRR 1207

  Fly   462 TFQMIME 468
            ..|.:::
Human  1208 EVQDVVK 1214

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl6	NP_788473.1	Methuselah_N	25..195	CDD:429053
		7tmB3_Methuselah-like	211..471	CDD:410632	61/313 (19%)
		TM helix 2	234..256	CDD:410632	6/24 (25%)
		TM helix 3	264..291	CDD:410632	6/26 (23%)
		TM helix 4	304..324	CDD:410632	6/19 (32%)
		TM helix 5	353..382	CDD:410632	7/29 (24%)
		TM helix 6	400..427	CDD:410632	6/28 (21%)
		TM helix 7	435..460	CDD:410632	4/24 (17%)
ADGRB2	NP_001351786.1	AGRB_N	38..230	CDD:465991
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	229..271
		TSP1	314..362	CDD:214559
		TSP1	367..417	CDD:214559
		TSP1	422..472	CDD:214559
		TSP1	478..528	CDD:214559
		HormR	531..595	CDD:214468
		GAIN	614..>769	CDD:465137
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	767..806
		GPS	870..923	CDD:197639	1/1 (100%)
		GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098	874..924		2/2 (100%)
		7tmB2_BAI2	929..1219	CDD:320654	65/324 (20%)
		TM helix 1	931..956	CDD:320654	10/29 (34%)
		TM helix 2	966..988	CDD:320654	6/26 (23%)
		TM helix 3	997..1025	CDD:320654	7/30 (23%)
		TM helix 4	1035..1055	CDD:320654	6/38 (16%)
		TM helix 5	1073..1102	CDD:320654	7/30 (23%)
		TM helix 6	1149..1176	CDD:320654	6/26 (23%)
		TM helix 7	1181..1206	CDD:320654	4/27 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1359..1385
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1423..1454
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1498..1585