DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl6 and ADGRG6

DIOPT Version :9

Sequence 1:	NP_788473.1	Gene:	mthl6 / 38839	FlyBaseID:	FBgn0035789	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	XP_006715579.1	Gene:	ADGRG6 / 57211	HGNCID:	13841	Length:	1251	Species:	Homo sapiens

Alignment Length:	552	Identity:	105/552 - (19%)
Similarity:	193/552 - (34%)	Gaps:	191/552 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LNILAIILVFVISSQSEAVIPGCDYFDTVDISHIPKLNDSY-----------AYEELIIPAHL-- 54
            :||....|...:||    ::||.:......|. :|..|:||           ....:|:|.:|
Human   673 VNITTRNLALSVSS----LLPGTNAISNFSIG-LPSNNESYFQMDFESGQVDPLASVILPPNLLE 732

  Fly    55 --------------------TGLYTFRQLADGSQEPVKSHLRACICKLKPCIRFCCPRNKMMPNS 99
                                |||:   |.....::.:.|::.|
Human   733 NLSPEDSVLVRRAQFTFFNKTGLF---QDVGPQRKTLVSYVMA---------------------- 772

  Fly   100 RCSDGLTENLKRINPYLKITLEDGTIGKYYLLTDMIVLRYEFRYCEKVVSVQEDQYKLYENGSFM 164
             ||.|            .||:::        |.|.:.::.:....::|.......:.|.:|.||
Human   773 -CSIG------------NITIQN--------LKDPVQIKIKHTRTQEVHHPICAFWDLNKNKSF- 815

  Fly   165 IKPDVNWTLSKQWYCLHPRLEDPN-SIWILEH-------VYIPKSMPAVPQVGT-----ISMVGC 216
                ..|..|.   |:..|..|.: ::.:..|       :.:|:|...:....|     ||.:||
Human   816 ----GGWNTSG---CVAHRDSDASETVCLCNHFTHFGVLMDLPRSASQLDARNTKVLTFISYIGC 873

  Fly   217 -------ILTIAVYLYIKKLR---------NLLGKCFICYVFCKFVQYLIWAGGDLNLWN--NIC 263
                   ..|:..|:..:|||         ||.....       |:..|....|.:..:|  .:|
Human   874 GISAIFSAATLLTYVAFEKLRRDYPSKILMNLSTALL-------FLNLLFLLDGWITSFNVDGLC 931

  Fly   264 SLAGYTNYFFALASHFWLSVMS-HQIWKNLRLINRDERSYHFLIYNIYGWGTPAIMTAI------ 321
            .......:||.||:..|:.:.: |.....:::.|...|.| .|.:.|.|||.||::.::
Human   932 IAVAVLLHFFLLATFTWMGLEAIHMYIALVKVFNTYIRRY-ILKFCIIGWGLPALVVSVVLASRN 995

  Fly   322 ---TYLVDWAWEDRPDKLNWIPGVGLYRCWINTYDWSAMIYL-----YGPMLILSLFNVVTFILT 378
               .|..:...:::.|:.          |||..   ..:.|:     :|.|..|   |:..||:.
Human   996 NNEVYGKESYGKEKGDEF----------CWIQD---PVIFYVTCAGYFGVMFFL---NIAMFIVV 1044

  Fly   379 VNHIMKIKSSVKSSTQQQRKCIQNNDFLLYLR----LSVMMGVT-GISEVITYFVKRHKFWRQVL 438
            :..|.. ::..:|:...:.:.::|      ||    |:.::|:| |.:    :|.     |.. |
Human  1045 MVQICG-RNGKRSNRTLREEVLRN------LRSVVSLTFLLGMTWGFA----FFA-----WGP-L 1092

  Fly   439 RVPNFFHLGS------GIVVFVLFILKRSTFQ 464
            .:| |.:|.|      |:.:|:.....:...|
Human  1093 NIP-FMYLFSIFNSLQGLFIFIFHCAMKENVQ 1123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl6	NP_788473.1	Mth_Ecto	25..197	CDD:119403	32/212 (15%)
mthl6	NP_788473.1	7tm_4	211..398	CDD:304433	46/219 (21%)
ADGRG6	XP_006715579.1	CUB	44..147	CDD:238001
		LamG	154..338	CDD:304605
		GPS	802..847	CDD:280071	10/52 (19%)
		7tm_4	864..1111	CDD:304433	61/288 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810