DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl6 and adgrd2

DIOPT Version :10

Sequence 1:NP_788473.1 Gene:mthl6 / 38839 FlyBaseID:FBgn0035789 Length:480 Species:Drosophila melanogaster
Sequence 2:XP_021334184.1 Gene:adgrd2 / 571770 ZFINID:ZDB-GENE-081104-190 Length:1145 Species:Danio rerio


Alignment Length:358 Identity:74/358 - (20%)
Similarity:136/358 - (37%) Gaps:104/358 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   174 SKQWYCLHPRLEDPNSIWILEHVYIPKSMPAVPQVG--TISMVG-----CILTIAVYLYI----- 226
            |...||.|     ..:..:|..:| .....||...|  .:|::|     |.|.....|::     
Zfish   765 STSCYCNH-----TTNFALLLQIY-EVQRDAVHDAGLQILSLIGSAVSLCALIFTFILFVAVGVP 823

  Fly   227 KKLRNLLGKCFICYVFCKFVQYLI----WAGGDLNLWNNICSLAGYTNYFFALASHFWLSVMSHQ 287
            |..|..:.|..:..:.  ..|:|:    ||.|.    ...|.|.....:.|.|:|..|:.|....
Zfish   824 KSDRTTVHKNLMAALI--VAQFLLILSDWAAGS----QEACWLVTALLHLFFLSSFCWMLVEGLL 882

  Fly   288 IWKNLRLINRDERSYHFLIYNIYGWGTPAIMTAITYLVDWAWEDRPDKLNWIPGVGLYR----CW 348
            :|..:..:|..| .....:|.:.|||.|.::.|:|.               :..:..|:    ||
Zfish   883 LWSKVVSVNISE-DRRMKMYYVLGWGLPVVIVAVTL---------------VATLDQYKAQQHCW 931

  Fly   349 INTYDWSAMIYLY-GPMLILSLFNVVTFILTVNHIMKIK---SSVKSSTQQQRKCIQNNDFLLY- 408
            :|..  |::|:.: ||:|         |:|.||.::..:   .:|.|:.::.:....::|..|: 
Zfish   932 LNLQ--SSVIWAFAGPVL---------FVLAVNAVVLFRVVLVTVSSARRRAKMLTPSSDSKLHT 985

  Fly   409 -----------LRLSVMMGVT-------GISEVITY-FVKRHKFWRQVLRVPNFFHLGSGIVVFV 454
                       |.|..::|:|       .:|:|:.| |:..:.|              .|:.:|:
Zfish   986 LDLTWAATRPVLILLPVLGLTWLCGVLVHLSDVMAYLFITLNAF--------------QGLYIFL 1036

  Fly   455 LFILKRSTFQMIMERISGPRR-------QQPAS 480
            ::.:..|..:..:.||...|:       .||.|
Zfish  1037 VYAVYNSEVRNAIRRIQEKRKALSFTNCSQPIS 1069

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl6NP_788473.1 Methuselah_N 25..195 CDD:429053 5/20 (25%)
7tmB3_Methuselah-like 211..471 CDD:410632 60/301 (20%)
TM helix 2 234..256 CDD:410632 6/25 (24%)
TM helix 3 264..291 CDD:410632 7/26 (27%)
TM helix 4 304..324 CDD:410632 7/19 (37%)
TM helix 5 353..382 CDD:410632 9/29 (31%)
TM helix 6 400..427 CDD:410632 9/46 (20%)
TM helix 7 435..460 CDD:410632 2/24 (8%)
adgrd2XP_021334184.1 LamG 204..402 CDD:473984
GPS 735..779 CDD:460350 4/18 (22%)
7tmB2_GPR144 792..1054 CDD:320383 62/308 (20%)
TM helix 1 794..819 CDD:320383 6/24 (25%)
TM helix 2 828..850 CDD:320383 3/23 (13%)
TM helix 3 859..886 CDD:320383 7/26 (27%)
TM helix 4 898..918 CDD:320383 7/34 (21%)
TM helix 5 935..964 CDD:320383 9/39 (23%)
TM helix 6 988..1015 CDD:320383 4/26 (15%)
TM helix 7 1017..1042 CDD:320383 6/38 (16%)
Blue background indicates that the domain is not in the aligned region.

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