DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl6 and adgrd2

DIOPT Version :9

Sequence 1:	NP_788473.1	Gene:	mthl6 / 38839	FlyBaseID:	FBgn0035789	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	XP_021334184.1	Gene:	adgrd2 / 571770	ZFINID:	ZDB-GENE-081104-190	Length:	1145	Species:	Danio rerio

Alignment Length:	358	Identity:	74/358 - (20%)
Similarity:	136/358 - (37%)	Gaps:	104/358 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 SKQWYCLHPRLEDPNSIWILEHVYIPKSMPAVPQVG--TISMVG-----CILTIAVYLYI----- 226
            |...||.|     ..:..:|..:| .....||...|  .:|::|     |.|.....|::
Zfish   765 STSCYCNH-----TTNFALLLQIY-EVQRDAVHDAGLQILSLIGSAVSLCALIFTFILFVAVGVP 823

  Fly   227 KKLRNLLGKCFICYVFCKFVQYLI----WAGGDLNLWNNICSLAGYTNYFFALASHFWLSVMSHQ 287
            |..|..:.|..:..:.  ..|:|:    ||.|.    ...|.|.....:.|.|:|..|:.|....
Zfish   824 KSDRTTVHKNLMAALI--VAQFLLILSDWAAGS----QEACWLVTALLHLFFLSSFCWMLVEGLL 882

  Fly   288 IWKNLRLINRDERSYHFLIYNIYGWGTPAIMTAITYLVDWAWEDRPDKLNWIPGVGLYR----CW 348
            :|..:..:|..| .....:|.:.|||.|.::.|:|.               :..:..|:    ||
Zfish   883 LWSKVVSVNISE-DRRMKMYYVLGWGLPVVIVAVTL---------------VATLDQYKAQQHCW 931

  Fly   349 INTYDWSAMIYLY-GPMLILSLFNVVTFILTVNHIMKIK---SSVKSSTQQQRKCIQNNDFLLY- 408
            :|..  |::|:.: ||:|         |:|.||.::..:   .:|.|:.::.:....::|..|:
Zfish   932 LNLQ--SSVIWAFAGPVL---------FVLAVNAVVLFRVVLVTVSSARRRAKMLTPSSDSKLHT 985

  Fly   409 -----------LRLSVMMGVT-------GISEVITY-FVKRHKFWRQVLRVPNFFHLGSGIVVFV 454
                       |.|..::|:|       .:|:|:.| |:..:.|              .|:.:|:
Zfish   986 LDLTWAATRPVLILLPVLGLTWLCGVLVHLSDVMAYLFITLNAF--------------QGLYIFL 1036

  Fly   455 LFILKRSTFQMIMERISGPRR-------QQPAS 480
            ::.:..|..:..:.||...|:       .||.|
Zfish  1037 VYAVYNSEVRNAIRRIQEKRKALSFTNCSQPIS 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl6	NP_788473.1	Mth_Ecto	25..197	CDD:119403	5/22 (23%)
mthl6	NP_788473.1	7tm_4	211..398	CDD:304433	45/208 (22%)
adgrd2	XP_021334184.1	LamG	204..402	CDD:328935
		GPS	735..779	CDD:307782	4/18 (22%)
		7tmB2_GPR144	792..1054	CDD:320383	62/308 (20%)
		TM helix 1	794..819	CDD:320383	6/24 (25%)
		TM helix 2	828..850	CDD:320383	3/23 (13%)
		TM helix 3	859..886	CDD:320383	7/26 (27%)
		TM helix 4	898..918	CDD:320383	7/34 (21%)
		TM helix 5	935..964	CDD:320383	9/39 (23%)
		TM helix 6	988..1015	CDD:320383	4/26 (15%)
		TM helix 7	1017..1042	CDD:320383	6/38 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910