DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl6 and adgrg6

DIOPT Version :9

Sequence 1:	NP_788473.1	Gene:	mthl6 / 38839	FlyBaseID:	FBgn0035789	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	NP_001356058.1	Gene:	adgrg6 / 561970	ZFINID:	ZDB-GENE-041014-357	Length:	1208	Species:	Danio rerio

Alignment Length:	288	Identity:	68/288 - (23%)
Similarity:	107/288 - (37%)	Gaps:	64/288 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 ISMVGC-------ILTIAVYLYIKKLR-----NLLGKCFICYVFCKFVQYLIWAGGDLNLW---- 259
            |:.:||       ..|:..|:..:|||     .:|.......:|...| :|      |:.|
Zfish   822 ITYIGCGISAIFSAATLLTYIAFEKLRRDYPSKILMNLSTSLLFLNMV-FL------LDGWLASY 879

  Fly   260 --NNICSLAGYTNYFFALASHFWLSVMS-HQIWKNLRLINRDERSYHFLIYNIYGWGTPAIMTAI 321
              ..:|.......:||.|.|..|:.:.| |.....:::.|...|.| .|.:.|.|||.||.:..|
Zfish   880 EIKELCVTVAVFLHFFLLTSFTWMGLESIHMYIALVKVFNTYIRRY-ILKFCIVGWGVPAAIVGI 943

  Fly   322 TYLVDWAWEDRPDKLNWI----PGVGLYR-CWI-NTYDWSAMIYLYGPMLILSLFNVVTFILTVN 380
            ...|.   :|...| |:.    .|.|... ||| |...:......|  ..|:.|.||..||:.:.
Zfish   944 VLAVS---KDSYGK-NYYGKGKDGQGTSEFCWILNPVVFYVTCVAY--FSIIFLMNVAMFIVVMI 1002

  Fly   381 HIMKIKSSVKSSTQQQRKCIQNNDFLLYLR----LSVMMGVT-GISEVITYFVKRHKFWRQV--- 437
            .|........:.|.::       |.|..||    |:.::|:| |.:    :|.     |..|
Zfish  1003 QICGRNGKRSNRTLRE-------DILRNLRSVVSLTFLLGMTWGFA----FFA-----WGPVSLA 1051

  Fly   438 -LRVPNFFHLGSGIVVFVLFILKRSTFQ 464
             :.:...|:...|:.:||.....:...|
Zfish  1052 FMYLFTIFNSLQGLFIFVFHCALKENVQ 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl6	NP_788473.1	Mth_Ecto	25..197	CDD:119403
mthl6	NP_788473.1	7tm_4	211..398	CDD:304433	52/211 (25%)
adgrg6	NP_001356058.1	CUB	41..146	CDD:278839
		LamG	153..336	CDD:354964
		GPS	756..801	CDD:334696
		7tmB2_GPR126	816..1086	CDD:320662	68/288 (24%)
		TM helix 1	818..843	CDD:320662	5/20 (25%)
		TM helix 2	853..875	CDD:320662	5/28 (18%)
		TM helix 3	886..913	CDD:320662	7/26 (27%)
		TM helix 4	928..944	CDD:320662	6/15 (40%)
		TM helix 5	975..998	CDD:320662	5/24 (21%)
		TM helix 6	1021..1046	CDD:320662	8/33 (24%)
		TM helix 7	1050..1075	CDD:320662	4/24 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810