Protein Alignment mthl6 and Adgrf2

DIOPT Version :10

• Sequence 1: NP_788473.1
• Gene: mthl6 / 38839
• FlyBaseID: FBgn0035789
• Length: 480
• Species: Drosophila melanogaster
• Sequence 2: XP_017173054.1
• Gene: Adgrf2 / 435529
• MGIID: 2182728
• Length: 673
• Species: Mus musculus
• Alignment Length: 397
• Identity: 83/397 - (20%)
• Similarity: 160/397 - (40%)
• Gaps: 115/397 - (28%)

  Fly   105 LTENLKRINPYLKITLEDG-----TIGKYYLLTDMIVLRYEFRYCEKVVSVQEDQ---------Y 155
            |.|.||.|:...:...:.|     .:|.:.|.:     |:::|.|:   ::||:.         .
Mouse   305 LPEELKNISLIFEKIRKSGERKSQCVGWHSLES-----RWDWRACK---TIQENSRQAVCRCRPN 361

  Fly   156 KLYENGSFMIKPDVNWTLSKQWYCLHPRLEDPNSIWILEHV-YIPKSMPAVPQVGTISMVGCI-L 218
            |||.:.|.::.|:.              ||.|    :|.:: ||...      :...|::.|: :
Mouse   362 KLYTSFSILMSPNT--------------LESP----VLTYITYIGLG------ISICSLIICLAI 402

  Fly   219 TIAVYLYIKK-----LRNLLGKCFICYVFCKFVQYLIW------AGGDLNLWNNICSLAGYTNYF 272
            .:.|:..:.|     ||:|   | |..:....:....|      ..|.: |.:|.|..|.:..:|
Mouse   403 EVLVWSQVTKTEISYLRHL---C-IANIAATLLMADAWFIVASFLSGPV-LHHNGCVAATFFVHF 462

  Fly   273 FALASHFWLSVMSHQIWKNLRLINRDERSYHFL--------IYNIYGWGTPAIMTAITYLVDWAW 329
            |.|:..||:...:..|...:.::      :|.|        :::: |:|.|.::..||..|.
Mouse   463 FYLSVFFWMLAKALLILYGILIV------FHTLPKSCLVASLFSV-GYGCPLVIAIITLAVT--- 517

  Fly   330 EDRPDKLNWIPGVGLYR---CWINTYDWSAMIYLYGPMLILSLFNVVTFILTVNHIMKIKSSVKS 391
                     .||.|..|   ||:|.....|::....|.|.:.:.|::|..:.:  |...::::.|
Mouse   518 ---------EPGKGYLRPEACWLNWDMTKALLAFVVPALAIVVVNLITVTMVI--IKTQRAAIGS 571

  Fly   392 STQQQRKCIQNNDFLLYLR-------LSVMMGVT---GISEVIT-YFVKRHKFWRQVLRVPNFFH 445
            |..|:.:.|        :|       |:.::|:|   ||:.||. :.:..|..:..:..:..||.
Mouse   572 SMFQEVRAI--------VRICKNIAILTPLLGLTWGFGIATVINGHSLAFHIIFSLLNALQGFFI 628

  Fly   446 LGSGIVV 452
            |..|.::
Mouse   629 LLFGTIL 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl6	NP_788473.1	Methuselah_N	25..195	CDD:429053	22/103 (21%)
		7tmB3_Methuselah-like	211..471	CDD:410632	59/276 (21%)
		TM helix 2	234..256	CDD:410632	4/27 (15%)
		TM helix 3	264..291	CDD:410632	7/26 (27%)
		TM helix 4	304..324	CDD:410632	6/27 (22%)
		TM helix 5	353..382	CDD:410632	5/28 (18%)
		TM helix 6	400..427	CDD:410632	9/37 (24%)
		TM helix 7	435..460	CDD:410632	4/18 (22%)
Adgrf2	XP_017173054.1	GPS	326..373	CDD:470616	11/54 (20%)
		7tmB2_GPR111_115	378..644	CDD:320660	63/302 (21%)
		TM helix 1	380..405	CDD:320660	5/30 (17%)
		TM helix 2	420..442	CDD:320660	4/25 (16%)
		TM helix 3	454..481	CDD:320660	7/26 (27%)
		TM helix 4	495..515	CDD:320660	5/20 (25%)
		TM helix 5	535..564	CDD:320660	6/30 (20%)
		TM helix 6	580..606	CDD:320660	7/33 (21%)
		TM helix 7	611..636	CDD:320660	5/25 (20%)