DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl6 and adgrl4

DIOPT Version :9

Sequence 1:	NP_788473.1	Gene:	mthl6 / 38839	FlyBaseID:	FBgn0035789	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	NP_998532.2	Gene:	adgrl4 / 406676	ZFINID:	ZDB-GENE-040426-2689	Length:	735	Species:	Danio rerio

Alignment Length:	290	Identity:	66/290 - (22%)
Similarity:	121/290 - (41%)	Gaps:	61/290 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 ILEHVYIPKSMPAVPQVG-TISMV---GCILTIAVYLYIKKLRNLLGKCFICYVFCKFVQYLIWA 252
            :|.|..:   :..:.|:| .||::   .||.|...:..|:..|..:.|...|.:|.....:||..
Zfish   465 LLAHYNV---LTRITQLGMVISLICLSMCIFTFWFFRDIQNTRTTIHKNLCCSLFMAQFIFLIGI 526

  Fly   253 GGDLNLWNNICSL-AGYTNYFFALASHFWLSVMSHQIWKNLRLINRDERSYHFLIYN-------- 308
            ....:.|  .||| ||..:||| ||:..|:.:....::  |.::.        :|||
Zfish   527 NKSAHKW--FCSLIAGLLHYFF-LAAFAWMCIEGIHLY--LIVVG--------VIYNKGFLHRNF 578

  Fly   309 -IYGWGTPAIMTAITYLVDWAWEDRPDKLNWIPGVGLYRCWI---NTYDWSAMIYLYGPMLILSL 369
             .:|:|:||::.||:..:.:.:......           ||:   |.:.||    ..||.:::.|
Zfish   579 YAFGYGSPAVVVAISATLGYKYYGTSSV-----------CWLSTENNFIWS----FIGPAILIIL 628

  Fly   370 FNVVTFILTVNHIMK---IKSSVKSSTQQQRKCIQNNDFLLYLRLSVMMGVTGISEVITYFVKRH 431
            .|::.|.:.:..:.:   :|....|..:..|.|.:....||:     ::|||....|: |.:...
Zfish   629 VNLLAFAVIIYKVYRHTAVKKPEISHYENIRSCARGAIALLF-----VLGVTWAFGVM-YILYET 687

  Fly   432 KFWRQVLRVPNFFHLGSGIVVFV-LFILKR 460
            .....:....|.|   .|:.:|: |.:|.|
Zfish   688 TLTAYLFTFANVF---QGMFIFIFLCVLSR 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl6	NP_788473.1	Mth_Ecto	25..197	CDD:119403	2/4 (50%)
mthl6	NP_788473.1	7tm_4	211..398	CDD:304433	46/205 (22%)
adgrl4	NP_998532.2	EGF_CA	34..56	CDD:304395
		EGF_CA	60..93	CDD:238011
		EGF_CA	110..143	CDD:214542
		GAIN	188..386	CDD:293098
		GPS	416..457	CDD:280071
		7tm_4	469..705	CDD:304433	60/275 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810