DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl6 and mthl10

DIOPT Version :9

Sequence 1:	NP_788473.1	Gene:	mthl6 / 38839	FlyBaseID:	FBgn0035789	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	NP_788446.2	Gene:	mthl10 / 38057	FlyBaseID:	FBgn0035132	Length:	585	Species:	Drosophila melanogaster

Alignment Length:	544	Identity:	158/544 - (29%)
Similarity:	255/544 - (46%)	Gaps:	96/544 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LLNILAIILVFVISSQSEAVIPG-----------------------CDYFDTVDIS-HIPKLNDS 42
            ||.:|.:: ||       .:|||                       |:::|||::: |....|.|
  Fly    18 LLGVLCLV-VF-------RLIPGIPFGTYVMAERDHYHTIDDPNVPCNFYDTVNLTGHRLFPNGS 74

  Fly    43 YAYEELIIPAHLTGLYTFRQLADGSQEPVKSHLRACICKLKPCIRFCCPRNKMMPNSRCSDGLTE 107
            |.|...|:||.|.|.|.:...:...:..|:.|:|.|:||.|.|:..|||..::. ||.....:.:
  Fly    75 YDYYGTIVPAELVGTYDYIHSSLTERIEVREHVRGCVCKFKSCLNICCPWRQVF-NSEVDGCIID 138

  Fly   108 NLKRIN----PYLKITLEDGTIGKYYLLTDMIVLRYEFRYCEKVVSVQE-----DQYKLYENGSF 163
            :.....    |.|.||..:.:.....:.|...:  ..||.|.|:.|:|.     |.|.|:||||
  Fly   139 HSDNRTWPDPPMLNITFRNESTILVNMFTQFAI--QSFRPCPKMFSLQPETNNWDDYLLFENGS- 200

  Fly   164 MIKPDVNWTLSKQWYCLHPRLEDPNSIWILEHVYIPKSMPAVPQVGTISMVG----------CIL 218
            |::.|....:.|..:|:.|...:.:.::...|   |.:........|:.::.          .:|
  Fly   201 MLRVDDKLLIRKNEFCMVPTYVNESDMFYTIH---PANCDMQDDHSTVKIINSYAMMFSIPFMML 262

  Fly   219 TIAVYLYIKKLRNLLGKCFICYV---------FCKFVQYLIWAGGDLNLWNNICSLAGYTNYFFA 274
            ||||||.|.:|||..||..:||:         .|....|.:.|.|      ..|.:.|||.|||.
  Fly   263 TIAVYLLIPELRNQHGKSLVCYLIGLSVGYSSLCYVQLYQVDATG------VTCKVFGYTAYFFF 321

  Fly   275 LASHFWLSVMSHQIWKNL---RLINRDERSYHFLIYNIYGWGTPAIMTAITYLVDWAWEDRPDKL 336
            :.::.||||:|..:|.|.   |.|||.:....||.|::|.||...:..|.||... ...:.|..|
  Fly   322 MGAYMWLSVISFDLWHNFRGTRGINRFQEKKRFLFYSLYSWGIALVFLAFTYCAQ-QLTNLPANL 385

  Fly   337 NWIPGV--GLYRCWINTYDWSAMIYLYGPMLILSLFNVVTFILTVNHIMKIKSSV------KSST 393
            .  ||:  |:| ||::..:|:||||.|||:|.:.:.|.:.||:|...|..::..:      ::||
  Fly   386 K--PGIGDGVY-CWLDMSNWAAMIYFYGPILAIVVANTIMFIMTAIKIHGVQREMARIIASENST 447

  Fly   394 QQQR--------KCIQNNDFLLYLRLSVMMGVTGISEVITYFVKRHKFWRQVLRVPNFFHLGSGI 450
            :..|        :...|..|.|:|||.::||:|.::|:|:|||...|.|.::..:.:..:...|.
  Fly   448 KNLRTEKDKRFYRAWSNYRFGLFLRLFLIMGITWLTELISYFVGSDKGWSKLFYISDLANAMQGF 512

  Fly   451 VVFVLFILKRSTFQMIMERISGPR 474
            ::|:||::|:....:|..|.|..|
  Fly   513 LIFMLFVMKKKVKHLITNRCSSVR 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl6	NP_788473.1	Mth_Ecto	25..197	CDD:119403	52/181 (29%)
mthl6	NP_788473.1	7tm_4	211..398	CDD:304433	71/224 (32%)
mthl10	NP_788446.2	Methuselah_N	56..236	CDD:284145	53/186 (28%)
mthl10	NP_788446.2	7tm_4	244..514	CDD:304433	89/279 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449111
Domainoid	1	1.000	49	1.000	Domainoid score	I4416
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5395
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	1	1.000	-	-		FOG0003851
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47154
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	7.000