DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl6 and mthl8

DIOPT Version :9

Sequence 1:	NP_788473.1	Gene:	mthl6 / 38839	FlyBaseID:	FBgn0035789	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	NP_001261182.1	Gene:	mthl8 / 38013	FlyBaseID:	FBgn0052475	Length:	492	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	110/521 - (21%)
Similarity:	202/521 - (38%)	Gaps:	106/521 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ILAIILVFVISSQS-----EAVIPGCDYFDTVDISHIPKLNDSYAYEELIIPAHLTGLYTFRQLA 64
            ||.::|:...:..|     |...| |.:.||.:|:....|:..:.:...:||.|...:|.| .:.
  Fly     6 ILGVLLILSGTHCSWGFHEETHYP-CAFIDTANITGSYGLDGPFVHNWTVIPRHFVAVYDF-VIE 68

  Fly    65 DGSQEPVKSHLRACICKLKPCIRFCCPRNK---------MMPNSRCSDGLTENLKRINPYLKITL 120
            :|.:.|...|||||:||.|||:|.||.|.:         ::|.:..|...:.:      ::::.|
  Fly    69 NGIRIPASRHLRACVCKTKPCVRICCLRGEIYDLEKRQCLVPVAGVSSLPSHS------HMEVEL 127

  Fly   121 EDGTIGKYYLLTDMIVLRYEFRY-----CEKVVSVQED----QYKLYENGSFMIKPDVNWTLSKQ 176
            .:|::       .::.|:..|..     ||.:.:|.:.    .:.|:|||:...:..:   .||.
  Fly   128 GNGSL-------RLVKLQPRFSIHVETPCEHMKAVTKGSEYVHWTLHENGTISHRGHI---FSKH 182

  Fly   177 WYCLHPRLEDPNSIWILEHV-YIPKSMPAVPQVG--------TISMVGCILTIAVYLYIKKLRN- 231
             ||..|.|.. ||.|..:.: ..|:.:..|..|.        .|:::...:.:.|||...::||
  Fly   183 -YCFTPLLHG-NSTWEWQPLACAPEKLYFVLGVREWTYAICLLIAILSMFIVLMVYLMCSEMRNS 245

  Fly   232 LLGKCFICYVFCKFVQYLIWA----GGDLNLWNNICSLAGYTNYFFALASHFWLSVMSHQIWKNL 292
            ..|.....|..|..:.|.:.|    ....||.|..|.:.........:.|.:.||.::.:::.:.
  Fly   246 FYGVAIKAYAICMILGYALLAYLTLHNPANLSNAACRILPSLALMNLVLSFYILSFIAFKLYLSF 310

  Fly   293 RLINRDERSYHFLIYNIYGW--GTPAIMTAITYLVDWAWEDRPDKLNWIPGVGLY---------R 346
                     |..:...:..|  .||.::.|:      .|       ::..|...|         .
  Fly   311 ---------YGVVFTKLMFWLIFTPIVLVAV------GW-------SFFVGFSYYGSRLIFGGDT 353

  Fly   347 CWINTYDWSAMIYLYGPMLILSLFNVVTFILTVNHIMKIKSSVKSSTQQQRKCIQNNDFLLYLRL 411
            ||.:..:||.|||.|.|:.:....:...::|:.   :.|:......|::..:.|:.|.|..:.:
  Fly   354 CWFDPRNWSVMIYFYAPVFVACAISGFFYVLSQ---IYIRDQPDIETEKSFESIEKNRFKSFWK- 414

  Fly   412 SVMMGVTGISEVI-------TYFVKRHKFWRQVLRVPNFFHLGSGIVVFVLFILKRSTFQMIMER 469
              ..|.|.:..|:       .|:.:........:.....||   |.......|.|....|..:.|
  Fly   415 --YFGYTAVVWVVCICSFAFNYYWENRSHLNYAVSFCMAFH---GFAALYALIGKNQQIQNFLRR 474

  Fly   470 I 470
            |
  Fly   475 I 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl6	NP_788473.1	Mth_Ecto	25..197	CDD:119403	48/190 (25%)
mthl6	NP_788473.1	7tm_4	211..398	CDD:304433	38/202 (19%)
mthl8	NP_001261182.1	Methuselah_N	30..202	CDD:284145	48/190 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462218
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	1	1.000	-	-		FOG0003851
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47154
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.950