Protein Alignment mthl6 and mthl4

DIOPT Version :10

• Sequence 1: NP_788473.1
• Gene: mthl6 / 38839
• FlyBaseID: FBgn0035789
• Length: 480
• Species: Drosophila melanogaster
• Sequence 2: NP_788394.1
• Gene: mthl4 / 36960
• FlyBaseID: FBgn0034219
• Length: 517
• Species: Drosophila melanogaster
• Alignment Length: 521
• Identity: 202/521 - (38%)
• Similarity: 300/521 - (57%)
• Gaps: 76/521 - (14%)

  Fly     3 LNILAIILVFVISSQSEAVIPGCDYFDTVDISHIPKL-NDSYAYEELIIPAHLTGLYTFRQLADG 66
            :.||.|.::|::..:|.|.|||||:|||||||..|:. |.||.||.|:||||||..|.::.|||.
  Fly     1 MRILLIAVLFLLMPKSNAEIPGCDFFDTVDISKAPRFSNGSYLYEGLLIPAHLTAEYDYKLLADD 65

  Fly    67 SQEPVKSHLRACICKLKPCIRFCCPRNKMMPNSRCSDGLTEN-LKRINPYLKITLEDGTIGKYYL 130
            |:|.|.||:|.|.|.|:||||||||:.:.|..|:|...::|: |.:.:|::.:||.||::.:.:.
  Fly    66 SKEKVASHVRGCACHLRPCIRFCCPQYQKMQKSKCYGDMSEDELNKHDPFVNVTLSDGSVVRRHF 130

  Fly   131 LTDMIV--------------LRYEFRYCEKVVSVQEDQYKLYENGSFMIKPDVNW---TLSKQWY 178
            ..|:||              |.:|         :..:::.|:||||.:    .:|   .|||:.|
  Fly   131 KEDLIVQSDLAKPGCPRMYFLNHE---------LPGNEFTLFENGSLL----RHWDKVELSKREY 182

  Fly   179 CL-HPRLEDPNSIWILEHVYIP---------KSMPAVPQVGTISMVGCILTIAVYLYIKKLRNLL 233
            |: |...:| :||.|..| :.|         |::..|     ||::..||||:||||::|||||.
  Fly   183 CVQHLSFKD-DSIRIAPH-FCPLSSEHSRTWKTVAIV-----ISLICIILTISVYLYVEKLRNLH 240

  Fly   234 GKCFICYVFCKFVQYLIWAGGDLNLW---NNICSLAGYTNYFFALASHFWLSVMSHQIWKNLRL- 294
            |||||||:...|:.|....   ||:|   :..|..||:..||..:|:.|||||    |..:||:
  Fly   241 GKCFICYLASLFLGYFFLV---LNVWKYSSGFCVTAGFLGYFSVMAAFFWLSV----IGIHLRIK 298

  Fly   295 -------INRDERSYHFLIYNIYGWGTPAIMTAITYLVDWAWEDRPDKLNWIPGVGLYRCWINTY 352
                   ::|......|..||:|.||.|.|||||||..|...::  :||....||| ..|||.|.
  Fly   299 FSLASNCLHRLLPENPFRAYNLYAWGIPLIMTAITYTADQVVKN--EKLRPRVGVG-KNCWIYTG 360

  Fly   353 DWSAMIYLYGPMLILSLFNVVTFILTVNHIMKIKSSVKSSTQQQRKCIQNND---FLLYLRLSVM 414
            |.:.|||.|||||:|..||::.|:|:..:|..||.:||....:|:...|.||   |.::|||.::
  Fly   361 DMTVMIYFYGPMLLLIAFNIIMFVLSAIYIYNIKKNVKGLVHKQQTNQQINDQQMFAIFLRLFIL 425

  Fly   415 MGVTGISEVITYFVKRHKFWRQVLRVPNFFHLGSGIVVFVLFILKRSTFQMIMERISGPRRQQPA 479
            ||::...|::::.:.:.:.|.:.|.|.::|:...|.::|||||||.|..::|   |:|.|:..|.
  Fly   426 MGLSWSFEILSFLLTKQQAWARALMVADYFNWSQGTIIFVLFILKPSILKLI---IAGGRQNLPG 487

  Fly   480 S 480
            |
  Fly   488 S 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl6	NP_788473.1	Methuselah_N	25..195	CDD:429053	74/189 (39%)
		7tmB3_Methuselah-like	211..471	CDD:410632	110/273 (40%)
		TM helix 2	234..256	CDD:410632	9/21 (43%)
		TM helix 3	264..291	CDD:410632	11/26 (42%)
		TM helix 4	304..324	CDD:410632	13/19 (68%)
		TM helix 5	353..382	CDD:410632	14/28 (50%)
		TM helix 6	400..427	CDD:410632	10/29 (34%)
		TM helix 7	435..460	CDD:410632	10/24 (42%)
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:429053	75/192 (39%)
		7tmB3_Methuselah-like	205..477	CDD:410632	111/286 (39%)
		TM helix 1	207..232	CDD:410632	10/29 (34%)
		TM helix 2	241..263	CDD:410632	11/24 (46%)
		TM helix 3	271..298	CDD:410632	13/30 (43%)
		TM helix 4	315..335	CDD:410632	13/19 (68%)
		TM helix 5	361..390	CDD:410632	14/28 (50%)
		TM helix 6	411..438	CDD:410632	9/26 (35%)
		TM helix 7	446..471	CDD:410632	10/24 (42%)