DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl6 and Adgrl3

DIOPT Version :9

Sequence 1:	NP_788473.1	Gene:	mthl6 / 38839	FlyBaseID:	FBgn0035789	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	XP_011247763.1	Gene:	Adgrl3 / 319387	MGIID:	2441950	Length:	1586	Species:	Mus musculus

Alignment Length:	420	Identity:	80/420 - (19%)
Similarity:	152/420 - (36%)	Gaps:	133/420 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 NPYLKITLEDGTIGKYYLLTDMIVLRYEFRYCEKVVSVQEDQYKLYENGSFMIKPDVNWTLSKQ- 176
            :|.:...:......|.| |.|.:|.        .|..:::.:.....|.||       |:.||:
Mouse   847 SPVITAAINKEFSNKVY-LADPVVF--------TVKHIKQSEENFNPNCSF-------WSYSKRT 895

  Fly   177 ----WYCLHPRLEDPNSIW-------------ILEHVYIPKS-------MPAVPQVG----TISM 213
                |.....||...|...             ::.||.:..|       :..:..||    .:.:
Mouse   896 MTGYWSTQGCRLLTTNKTHTTCSCNHLTNFAVLMAHVEVKHSDAVHDLLLDVITWVGILLSLVCL 960

  Fly   214 VGCILTIAVYLYIKKLRNLLGKCFICYVFCKFVQYLIWAGGDLNLWNN--ICSLAGYTNYFFALA 276
            :.||.|...:..::..||.:.|.....:|...:.:||    .:|..:.  .|::.....:||.||
Mouse   961 LICIFTFCFFRGLQSDRNTIHKNLCISLFVAELLFLI----GINRTDQPIACAVFAALLHFFFLA 1021

  Fly   277 SHFWLSVMSHQIWKNLRLINRDE---RSYHFLIYNIYGWGTPAIMTAITYLVDWAWEDRPDKLNW 338
            :..|:.:...|::..|..:...|   |.|.:|:    |:|.||::.|::..||:. ....||:
Mouse  1022 AFTWMFLEGVQLYIMLVEVFESEHSRRKYFYLV----GYGMPALIVAVSAAVDYR-SYGTDKV-- 1079

  Fly   339 IPGVGLYRCW--INTY-DWSAMIYLYGPMLILSLFNVVTFILTV----NH--IMKIKSSVKSSTQ 394
                    ||  ::|| .||    ..||..::.:.||:...:.:    :|  |:|.:|.
Mouse  1080 --------CWLRLDTYFIWS----FIGPATLIIMLNVIFLGIALYKMFHHTAILKPESG------ 1126

  Fly   395 QQRKCIQNNDF-----------------LLYLRLSVMMGVTGISE---VITYFVKRHKFWRQVLR 439
                |:.|.::                 |..|.|:...|:..|:|   ::.|..
Mouse  1127 ----CLDNINYEDNRPFIKSWVIGAIALLCLLGLTWAFGLMYINESTVIMAYLF----------- 1176

  Fly   440 VPNFFHLGSGIVVFVLFILKRSTFQMIMER 469
              ..|:...|:.:|:        |..::::
Mouse  1177 --TIFNSLQGMFIFI--------FHCVLQK 1196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl6	NP_788473.1	Mth_Ecto	25..197	CDD:119403	18/101 (18%)
mthl6	NP_788473.1	7tm_4	211..398	CDD:304433	45/200 (23%)
Adgrl3	XP_011247763.1	Gal_Lectin	111..191	CDD:366935
		OLF	205..461	CDD:128580
		HormR	563..627	CDD:214468
		GAIN	636..856	CDD:374574	1/8 (13%)
		GPS	882..934	CDD:197639	12/58 (21%)
		7tmB2_Latrophilin-3	942..1208	CDD:320671	60/309 (19%)
		TM helix 1	945..969	CDD:320671	5/23 (22%)
		TM helix 2	978..999	CDD:320671	5/24 (21%)
		TM helix 3	1009..1031	CDD:320671	5/21 (24%)
		TM helix 4	1050..1066	CDD:320671	7/19 (37%)
		TM helix 5	1085..1108	CDD:320671	8/26 (31%)
		TM helix 6	1141..1166	CDD:320671	4/24 (17%)
		TM helix 7	1170..1195	CDD:320671	5/45 (11%)
		Latrophilin	1208..1586	CDD:367050
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810