DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl6 and mthl14

DIOPT Version :9

Sequence 1:	NP_788473.1	Gene:	mthl6 / 38839	FlyBaseID:	FBgn0035789	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	NP_728509.1	Gene:	mthl14 / 318046	FlyBaseID:	FBgn0052476	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	544	Identity:	107/544 - (19%)
Similarity:	209/544 - (38%)	Gaps:	121/544 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LLNILAIILVFVISSQSEAVIPGCDYFDTVDISHIPKLN-------DSYAYEELIIP-------A 52
            ||.::::...|..|:|...|.......:..:|.|....|       |:..:..|::|       |
  Fly     9 LLALISLQTFFNASAQISTVNNSSKGSNNSNIFHEDTFNSTSIDVLDASIHSTLVVPQTYSTEAA 73

  Fly    53 HLTGLYTFRQLADGSQEPVKSHLRACIC------KLKPC------IRFCCPRNKMM-------PN 98
            .::|......:.  .|.||.:.|....|      :.:|.      :|.|||..:.:       .:
  Fly    74 TISGARFATSVP--VQSPVDNPLDPADCSQREKYRKQPVATPSSRLRKCCPHGENLNIYRENQSD 136

  Fly    99 SRCSDGLTENLKRINPYLKITLEDGTIGKYYLLTDMIVLRYEF-RYCEK--VVSVQEDQYKLYEN 160
            |.|.:||......|   :...|.|..|....:.|   .|.|:. ..|..  :...::|.:.:.::
  Fly   137 SMCDNGLLSFEPTI---ISAVLFDNCIEDLEVET---TLDYDIGNPCNSSLLYDDKDDVFFVLQD 195

  Fly   161 GSFMIKP---DVNWTLSKQWYCLHPRLEDPNSIWILEHVYIPKSMPAVPQVGTISM-----VGCI 217
            ||.:|..   :.::|: |:.|||.  ::....::....|...:...|..:|..:::     :.|:
  Fly   196 GSLLIIDKFGNESYTV-KEHYCLD--IDKSGHLFAFTCVTQVEEQIAFAKVVFVAVLMLISMPCL 257

  Fly   218 LTIA-VYLYIKKLRNLLGKCF----ICYVFCKFVQYLIWAGGDLNLWNNICSLAGYTNYFFALAS 277
            |.:: :::.::.||||.|...    :|.....||..::...|..|.     ...||...|..|:.
  Fly   258 LLVSYLHMTLRLLRNLHGLSLSLMSLCLASGYFVHSVVHIYGIPNQ-----GFIGYVIQFCILSY 317

  Fly   278 HFW-----LSVMSHQIWKNLRLINRDERS---YHFLIYNIYGWGTPAIMTAIT----------YL 324
            .||     .:|:.: :|..|....:..:|   ::|..|.::.:..||.:.|:|          |.
  Fly   318 FFWYLCICFNVLLN-VWYKLPCCIQCSKSWATFNFACYAVFAFSGPATIVALTVQKGLPGMPSYF 381

  Fly   325 VDWAWED-RPDKLNWIPGVGLYRCWINTYDWSAMIYLYGPMLILS-LFNVVTFILTVNHIMKIKS 387
            :....|. |..:..:||.|                   ..:|.|| |.|:::|.    ...:|..
  Fly   382 LQGLTESIRDSQRYFIPPV-------------------STILFLSFLLNIISFF----GFQRISG 423

  Fly   388 SVKSSTQ-QQRKCI--------QNNDFLLYLRLSVMMGVTGISEVITYFVKRHKFWRQVLRVPNF 443
            ..|:... |:|||:        ...|......|.::|.|:.:.|:||::...:..:..:..:.|.
  Fly   424 YAKAEKNIQERKCLFDQQKYEDVKKDAKCVSLLGIIMVVSWLLEIITFYSGSNSNYLILCDMVNG 488

  Fly   444 FHLGSGIVVFVLFILKRSTFQMIM 467
            .   .|:.|.::|::.|....:|:
  Fly   489 L---QGVWVLLIFLVVRRRRTIIL 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl6	NP_788473.1	Mth_Ecto	25..197	CDD:119403	39/210 (19%)
mthl6	NP_788473.1	7tm_4	211..398	CDD:304433	43/217 (20%)
mthl14	NP_728509.1	7tmB3_Methuselah-like	239..512	CDD:320167	61/303 (20%)
		TM helix 1	241..266	CDD:320167	3/24 (13%)
		TM helix 2	275..297	CDD:320167	4/21 (19%)
		TM helix 3	306..331	CDD:320167	7/24 (29%)
		TM helix 4	349..369	CDD:320167	5/19 (26%)
		TM helix 5	389..418	CDD:320167	10/51 (20%)
		TM helix 6	445..472	CDD:320167	7/26 (27%)
		TM helix 7	477..502	CDD:320167	4/27 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462175
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840