DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl6 and Adgre1

DIOPT Version :9

Sequence 1:	NP_788473.1	Gene:	mthl6 / 38839	FlyBaseID:	FBgn0035789	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	NP_001007558.1	Gene:	Adgre1 / 316137	RGDID:	1359214	Length:	932	Species:	Rattus norvegicus

Alignment Length:	446	Identity:	92/446 - (20%)
Similarity:	165/446 - (36%)	Gaps:	129/446 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FVISSQSEAVIPGCDYFDTVDISHIPKLNDSYAYEE------LIIPAHLTGLYTFRQLADGSQEP 70
            |:|........||..:   |..:|:..:.|...:|:      |.:.:|:.|.....:..:...:|
  Rat   516 FIIKESESTGTPGVAF---VSFAHMDSVLDERFFEDGQASWKLRMNSHVVGGTVTGERKEDFSKP 577

  Fly    71 V---KSHLRACICKLKPCIRFCCPRNKMMPNSRCSDGLTENLKRINPYLKITLEDGTIGKYYLLT 132
            :   ..|::              |:.| ...|.|....|:            :|||
  Rat   578 IVYTLQHIQ--------------PKQK-SERSICVSWNTD------------VEDG--------- 606

  Fly   133 DMIVLRYEFRYCEKVVSVQEDQYKLYENGSFMIKPDVNWTLSKQWYCLHPRLEDPNSIWILEHVY 197
                 |:....||.|.:.:                       ....|...|:.:...|.....:.
  Rat   607 -----RWTPSGCETVEASE-----------------------THTVCSCNRMTNLAIIMASGELT 643

  Fly   198 IPKSMPAVPQVGT-ISMVGCILTIAVYLYIKKLRNLLGKCFICYVFCKFVQYLIWAGG-DLNLWN 260
            :..|:..:..||| ||:|...|.||.:|..:.::|......:....|.|:..:::..| |.....
  Rat   644 MEFSLYIISYVGTVISLVCLALAIATFLLFRAVQNHNTYLHLHLCVCLFLAKILFLTGIDKTDNQ 708

  Fly   261 NICS-LAGYTNYFFALASHFWL---SVMSHQIWKNLRLINR-DERSYHFLIYNIYGWGTPAIMTA 320
            ..|: :||:.:|.| ||..||:   :||...:.:||:::|. ..|:...|....:|:|.|.::..
  Rat   709 TACAIIAGFLHYLF-LACFFWMLVEAVMLFLMVRNLKVVNYFSSRNIKMLHLCAFGYGLPVVVVI 772

  Fly   321 ITYLVDWAWEDRPDKLNWIPGVGLY-RCWINT---YDWSAMIYLYGPMLILSLFNVVTFILTVNH 381
            |:..|. .|           |.|:: |||:||   :.||.:    ||         |..|:|:|
  Rat   773 ISATVH-PW-----------GYGMHNRCWLNTETGFIWSFL----GP---------VCMIITIN- 811

  Fly   382 IMKIKSSVKSST---QQQRKCIQNNDF-------LLYLRLSVMMGVTGISEVITYF 427
                 |::.:.|   .:|:.|..|::.       ||..:....:.:.|.|.|:..|
  Rat   812 -----SALLAWTLWVLRQKLCSVNSEVSKLKDTRLLTFKAIAQIFILGCSWVLGIF 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl6	NP_788473.1	Mth_Ecto	25..197	CDD:119403	24/180 (13%)
mthl6	NP_788473.1	7tm_4	211..398	CDD:304433	52/199 (26%)
Adgre1	NP_001007558.1	EGF_CA	33..63	CDD:238011
		EGF_CA	81..>109	CDD:214542
		EGF_CA	133..172	CDD:214542
		EGF_CA	173..>203	CDD:214542
		EGF_CA	222..255	CDD:214542
		cEGF	245..275	CDD:289433
		EGF_CA	272..>301	CDD:214542
		EGF_CA	319..359	CDD:284955
		Cell attachment site. /evidence=ECO:0000255	507..509
		GPS	592..641	CDD:197639	13/97 (13%)
		7tm_2	646..886	CDD:278432	64/249 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810