DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl6 and ADGRE2

DIOPT Version :10

Sequence 1:NP_788473.1 Gene:mthl6 / 38839 FlyBaseID:FBgn0035789 Length:480 Species:Drosophila melanogaster
Sequence 2:XP_054176753.1 Gene:ADGRE2 / 30817 HGNCID:3337 Length:892 Species:Homo sapiens


Alignment Length:293 Identity:55/293 - (18%)
Similarity:119/293 - (40%) Gaps:61/293 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   192 ILEHVYIPKSMPAVPQVG----TISMVGCILTIAVYLYIKKLRNLLGKCFICYVFCKFVQYLIW- 251
            ::.|..:.:..|.:..:.    ::|::..:|....:|..|.::|......:....|.|:.:|:: 
Human   592 LMAHYDVQEEDPVLTVITYMGLSVSLLCLLLAALTFLLCKAIQNTSTSLHLQLSLCLFLAHLLFL 656

  Fly   252 AGGDLNLWNNICSLAGYTNYFFALASHFWLSVMSHQIW---KNLRLINRD--ERSYHFLIYNIYG 311
            ...|......:||:...|.::..||:..|:.:.:..::   :||.::|..  .|....|::.: |
Human   657 VAIDQTGHKVLCSIIAGTLHYLYLATLTWMLLEALYLFLTARNLTVVNYSSINRFMKKLMFPV-G 720

  Fly   312 WGTPAIMTAITYLVDWAWEDRPDKLNWIPGVGLY----RCWINT---YDWSAMIYLYGPMLILSL 369
            :|.||:..||:.      ..||.         ||    |||:..   :.|..:    ||:..:..
Human   721 YGVPAVTVAISA------ASRPH---------LYGTPSRCWLQPEKGFIWGFL----GPVCAIFS 766

  Fly   370 FNVVTFILTV----NHIMKIKSSVKSSTQQQRKCIQNNDFLLYLRLSVMMGVTGI---SEVITYF 427
            .|:|.|::|:    |.:..:.|.|.:....:....:....|..|..:..:|:..:   :.|:.|.
Human   767 VNLVLFLVTLWILKNRLSSLNSEVSTLRNTRMLAFKATAQLFILGCTWCLGILQVGPAARVMAYL 831

  Fly   428 VKRHKFWRQVLRVPNFFHLGS--GIVVFVLFIL 458
                           |..:.|  |:.:|:::.|
Human   832 ---------------FTIINSLQGVFIFLVYCL 849

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl6NP_788473.1 Methuselah_N 25..195 CDD:429053 0/2 (0%)
7tmB3_Methuselah-like 211..471 CDD:410632 53/270 (20%)
TM helix 2 234..256 CDD:410632 3/22 (14%)
TM helix 3 264..291 CDD:410632 5/29 (17%)
TM helix 4 304..324 CDD:410632 7/19 (37%)
TM helix 5 353..382 CDD:410632 8/32 (25%)
TM helix 6 400..427 CDD:410632 4/29 (14%)
TM helix 7 435..460 CDD:410632 5/26 (19%)
ADGRE2XP_054176753.1 EGF_CA 136..168 CDD:429571
EGF_CA 188..>220 CDD:214542
EGF_CA 232..263 CDD:429571
EGF_CA 281..312 CDD:429571
GPS 548..598 CDD:197639 1/5 (20%)
7tmB2_EMR 602..864 CDD:320555 54/283 (19%)
TM helix 1 604..629 CDD:320555 2/24 (8%)
TM helix 2 638..660 CDD:320555 3/21 (14%)
TM helix 3 669..696 CDD:320555 5/26 (19%)
TM helix 4 713..733 CDD:320555 7/26 (27%)
TM helix 5 750..773 CDD:320555 5/26 (19%)
TM helix 6 797..822 CDD:320555 3/24 (13%)
TM helix 7 826..851 CDD:320555 7/39 (18%)
Blue background indicates that the domain is not in the aligned region.

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