DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl6 and Adgrf2

DIOPT Version :9

Sequence 1:	NP_788473.1	Gene:	mthl6 / 38839	FlyBaseID:	FBgn0035789	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	XP_017452241.2	Gene:	Adgrf2 / 301269	RGDID:	1306718	Length:	654	Species:	Rattus norvegicus

Alignment Length:	432	Identity:	75/432 - (17%)
Similarity:	144/432 - (33%)	Gaps:	156/432 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 PRNKMMPNSRCSDGLTENLKRINPYLKITLED------------------GTIGKYYLLTDM--- 134
            |||.:..|...|..:.:...::...:.:|.|:                  |.|.:..||.:|
  Rat   237 PRNSLGKNFTFSMRVNDTSDKVTGRILLTTEELQKVPSAFQVISIAFPTLGAILEASLLENMTVN 301

  Fly   135 -----IVLRYEFRYCEKVVSVQEDQYKLYENGSFMIKPDVNWTLSKQWYCLHPRLE--------- 185
                 ::|..|.:   .:..:.|...|..|..|..:          .|:.|..|.:
  Rat   302 GLVLSVILPKELK---NISLIFEKIRKSGERKSQCV----------GWHSLESRWDRRACKMIQE 353

  Fly   186 ---------DPNSIWILEHVYIPKSMPAVPQVGTISMVGCILTIAVYLYIKKLRNLLGKCFICYV 241
                     .||..:....:.:..:....|.:..|:.:|                 ||......:
  Rat   354 NSRQAICRCQPNKFFTSFSILMSPNTVESPVLTYITYIG-----------------LGISICSLI 401

  Fly   242 FCKFVQYLIWAGGD---------------------LNLW-------------NNICSLAGYTNYF 272
            .|..::.|:|:...                     .::|             :|.|..|.:..:|
  Rat   402 ICLAIEALVWSQVTKTEISYLRHLCIANIAVTLLMADVWFIVASFLSGPIVHHNGCVTATFFVHF 466

  Fly   273 FALASHFWLSVMSHQIWKNLRLINRDERSYH-----FLIYNIY--GWGTPAIMTAITYLVDWAWE 330
            |.|:..||:...:..|...:.::      :|     .|:.:::  |:|.|.::..||..|.
  Rat   467 FYLSVFFWMLAKALLILYGILIV------FHTLPKSCLVASLFTVGYGCPLVIAVITLAVT---- 521

  Fly   331 DRPDKLNWIPGVGLYR---CWINTYDWSAMIYLYGPMLILSLFNVVTFILTVNHIMKIKSSVKSS 392
                    .||.|..|   ||:|.....|::....|.|.:.:.|::|..|.:  |...:::|.||
  Rat   522 --------EPGKGYLRPEACWLNWDMTKALLAFVVPALAIVVVNLITVTLVI--IKTQRAAVGSS 576

  Fly   393 TQQQRKCIQNNDFLLYLR-------LSVMMGVT---GISEVI 424
            ..|:.:.|        :|       |:.::|:|   ||:.|:
  Rat   577 MFQEVRAI--------VRICKNIAILTPLLGLTWGFGIATVV 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl6	NP_788473.1	Mth_Ecto	25..197	CDD:119403	23/149 (15%)
mthl6	NP_788473.1	7tm_4	211..398	CDD:304433	43/230 (19%)
Adgrf2	XP_017452241.2	GPS	330..377	CDD:413374	6/56 (11%)
		7tm_GPCRs	382..628	CDD:421689	52/274 (19%)
		TM helix 1	384..409	CDD:410628	5/41 (12%)
		TM helix 2	424..446	CDD:410628	1/21 (5%)
		TM helix 3	458..485	CDD:410628	7/26 (27%)
		TM helix 4	499..519	CDD:410628	5/19 (26%)
		TM helix 5	539..568	CDD:410628	7/30 (23%)
		TM helix 6	584..610	CDD:410628	7/33 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910