DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl6 and Adgrf3

DIOPT Version :9

Sequence 1:	NP_788473.1	Gene:	mthl6 / 38839	FlyBaseID:	FBgn0035789	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	XP_006239862.1	Gene:	Adgrf3 / 298857	RGDID:	1305868	Length:	992	Species:	Rattus norvegicus

Alignment Length:	442	Identity:	82/442 - (18%)
Similarity:	154/442 - (34%)	Gaps:	129/442 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 LKRINPYLKITLEDGTIGKYYLLTDMIVLRYEFRYCEKVVSVQEDQYKLYENGSFMIKPDVNWTL 173
            |::::..|......|.....|....||:          |:|:..|.....:....|...|:|.||
  Rat   580 LQKLDSRLPSNYRQGLRDTSYATPGMIL----------VISITADGQDFTQAEVIMDFEDMNGTL 634

  Fly   174 -----------------------------SKQWYCLHPRLEDPNSIWILEHVYIPKSMPAVPQVG 209
                                         :.|..|.|   ....||.:.:|     ::|..|.:.
  Rat   635 HCVFWDHNAFQGRGGWSDEGCELQAANASAVQCVCRH---LTAFSILMSQH-----AVPEDPLLD 691

  Fly   210 TISMVG---CILTIAVYLYIKKL------RNLLG----KCFICYVFCKFVQYLIWAGGDLNLW-- 259
            .:|.||   .||.:.|.|.|.:|      ||.:.    ......|.|..|....:.|   |.|
  Rat   692 LLSQVGVGASILALLVCLVIYRLVWRVVVRNKVAFFRHTALFNMVICLLVADTCFLG---NPWLP 753

  Fly   260 ----NNICSLAGYTNYFFALASHFWL----SVMSHQIWKNLRLINRDERSYHFLIYNIYGWGTPA 316
                :.:|....:..:||.||:.||:    .|::||:   |.:.::..:.....:.:|.|:..|.
  Rat   754 SGYHSLVCLATAFLCHFFYLATFFWMLAQALVLAHQL---LFVFHQLSKPLVLSMMSILGYLCPL 815

  Fly   317 IMTAITYLVDWAWEDRPDKLNWIPGVGLY----------RCWINTYDWSAMIYLYGPMLILSLFN 371
            ....:|                   :|||          :|.::. |..::.....|:|.:...|
  Rat   816 GFAGVT-------------------LGLYLPQRKYLREGKCLLSG-DGVSLHAFSEPVLAIVSVN 860

  Fly   372 VVTFILTVNHIMKIKSSVKSSTQQQRKCIQNNDFLLYLR----LSVMMGVTGISE--VITYFVKR 430
            .:..::.|..:::...|...:.::::..:.....||.|.    |:..:|||.:.|  ::.:::
  Rat   861 GLVLVIAVLKLLRPSLSEGPAVEKRQALVGVLKALLILTPIFGLTWGLGVTTLFEGSLVFHYI-- 923

  Fly   431 HKFWRQVLRVPNFFHLGS--GIVVFVLFIL-KRSTFQMIMERISGPRRQQPA 479
                        |..|.|  |:.:||...| .:...:.:.:.:.|.|....|
  Rat   924 ------------FVILNSLQGVFIFVFGCLTDKKVLEALRKWLRGSRSSNSA 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl6	NP_788473.1	Mth_Ecto	25..197	CDD:119403	20/116 (17%)
mthl6	NP_788473.1	7tm_4	211..398	CDD:304433	42/219 (19%)
Adgrf3	XP_006239862.1	HRM	353..>395	CDD:295297
		GPS	632..679	CDD:197639	7/49 (14%)
		7tm_4	687..935	CDD:304433	55/287 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810