DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl6 and CG15744

DIOPT Version :9

Sequence 1:	NP_788473.1	Gene:	mthl6 / 38839	FlyBaseID:	FBgn0035789	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	NP_572870.2	Gene:	CG15744 / 2768909	FlyBaseID:	FBgn0030466	Length:	1797	Species:	Drosophila melanogaster

Alignment Length:	415	Identity:	79/415 - (19%)
Similarity:	135/415 - (32%)	Gaps:	146/415 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 ISHIPKLN-----DSYAYEELIIPAHLTGLYTFRQ-----LADGSQEPVKSHLRACICKLKPCIR 87
            ::|:.||.     .|:.||.           ||.|     |.|.|..|:     ||.|.|...|.
  Fly   131 LAHLEKLKLAGNAISHIYEG-----------TFDQMPKLKLLDLSGNPL-----ACDCGLIWLIA 179

  Fly    88 FCCPRN-KMMPNSRC-SDGLTENLKRINPYLKITLEDGTIGKYYLLTDMIVLRYEFRYCEKVVS- 149
            :...|. ::.|..:| |.|   |.:.: |..|:     .:||.:             :||.::.
  Fly   180 WSSSREVRLQPPPKCESPG---NFRGM-PLKKL-----RVGKDF-------------HCETLLQP 222

  Fly   150 ----VQEDQYKLYENGSFMIKPDVNWTLSKQWYCLHPRLEDPNSIWILEHVYIPKSMPAVPQVGT 210
                :.......:|.....:|            |..||:.          :.:|:....:|....
  Fly   223 LLELIPSQNQVAFEGDELQLK------------CHAPRVA----------IGVPRESEDLPTKAY 265

  Fly   211 ISMVGCILTIAVYLYIKKLRNLLGKCFICY-----VFCKFVQYLIWAGGDLNLWNNICSLAGYTN 270
            :          .:.:.:|:|.......|.|     ||           ||:||.....:.:|...
  Fly   266 V----------FWGWSEKIRAKNSTEDIIYQDPTKVF-----------GDVNLETRHSTDSGILQ 309

  Fly   271 YFFALAS----H--FW------------LSVMSHQIWK-----NLRLINRDERSYHFLIYNIYGW 312
            ....:||    |  .|            .:::.|.:.|     ..|:::.::.:||        |
  Fly   310 SILRIASLTQNHTGMWDCTLRSQQANLSQAIVLHVVAKGTLYCEARVVHTNKGTYH--------W 366

  Fly   313 GTPAIMTAITYLVDWAWEDRPDKLNWIPGVGLYRC-----WINTYDWSAMIYLYGPMLILSLFNV 372
              |..|...|.|.:.. |:..|...  .....:.|     |:| .|..:.:|:.....||..|..
  Fly   367 --PRTMRGETVLQECV-EEPSDATQ--ARRASHECGPSGEWLN-LDTESCVYVSETTRILEQFAK 425

  Fly   373 VTFILTV-NHIMKIKSSVKSSTQQQ 396
            |...||. .:.::|...:.:.||.|
  Fly   426 VNLTLTKGQNALEIARRLHNFTQAQ 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl6	NP_788473.1	Mth_Ecto	25..197	CDD:119403	35/180 (19%)
mthl6	NP_788473.1	7tm_4	211..398	CDD:304433	42/220 (19%)
CG15744	NP_572870.2	LRR_8	107..168	CDD:290566	12/47 (26%)
		LRR_4	107..147	CDD:289563	4/15 (27%)
		leucine-rich repeat	109..133	CDD:275378	0/1 (0%)
		leucine-rich repeat	134..157	CDD:275378	8/33 (24%)
		LRRCT	166..216	CDD:214507	16/76 (21%)
		IG_like	229..344	CDD:214653	22/157 (14%)
		HRM	<366..412	CDD:295297	11/51 (22%)
		7tm_4	768..>975	CDD:304433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462156
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930