DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl6 and ADGRF1

DIOPT Version :9

Sequence 1:NP_788473.1 Gene:mthl6 / 38839 FlyBaseID:FBgn0035789 Length:480 Species:Drosophila melanogaster
Sequence 2:NP_722582.2 Gene:ADGRF1 / 266977 HGNCID:18990 Length:910 Species:Homo sapiens


Alignment Length:551 Identity:115/551 - (20%)
Similarity:208/551 - (37%) Gaps:127/551 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MLLNILAIILVF---VISSQSEAVIPGCD-YFDTVDISHIPKL--NDSYAYEEL---------II 50
            :|.||.::.|..   |.:|..|.||...| ..::..:::...|  .:.||...|         ::
Human   351 ILSNISSLSLASHFRVSNSTMEDVISIADNILNSASVTNWTVLLREEKYASSRLLETLENISTLV 415

  Fly    51 PAHLTGLYTFRQLADGSQEPV-KSHL-RACICKLKPCIRFCCPRNKMMP-NSRCSDGLTENLKRI 112
            |.....|...|:..|....|| ||.| |....::|     .||:|..:| ..|...| ::..:|.
Human   416 PPTALPLNFSRKFIDWKGIPVNKSQLKRGYSYQIK-----MCPQNTSIPIRGRVLIG-SDQFQRS 474

  Fly   113 NPYLKITLEDGTIGKYYLLTDMIVLRYEFRYCEKVVSVQEDQYKLYENGSFMIKPDVN------- 170
            .|...|::...|:|....::.    ....:....|:|.....|.:.|...|..|.:.|       
Human   475 LPETIISMASLTLGNILPVSK----NGNAQVNGPVISTVIQNYSINEVFLFFSKIESNLSQPHCV 535

  Fly   171 -WTLSK-QW-----------------YCLHPRLEDPNSIWILEHVYIPKSMPAVPQVGTISMVG- 215
             |..|. ||                 .|.|     ..|..||...::|.::  .|.|..|:.|| 
Human   536 FWDFSHLQWNDAGCHLVNETQDIVTCQCTH-----LTSFSILMSPFVPSTI--FPVVKWITYVGL 593

  Fly   216 ---------CILTIAVY-LYIKKLRNLLGKCFICYV------FCKFVQYLIWAGGDLNL-WNNIC 263
                     |::..|:: ..|||.:....: .||.|      ....|.:::.|..|..: .:.:|
Human   594 GISIGSLILCLIIEALFWKQIKKSQTSHTR-RICMVNIALSLLIADVWFIVGATVDTTVNPSGVC 657

  Fly   264 SLAGYTNYFFALASHFWLSVMSHQIWKNLRLINRDERSYHFLIYNI-------YGWGTPAIMTAI 321
            :.|.:..:||.|:..||:.::...:...:.|:      :|.:..::       .|:|.|.|::.|
Human   658 TAAVFFTHFFYLSLFFWMLMLGILLAYRIILV------FHHMAQHLMMAVGFCLGYGCPLIISVI 716

  Fly   322 TYLVDWAWEDRPDKLNWIPGVGLYR----CWINTYDWS----AMIYLYGPMLILSLFNVVTFILT 378
            |..|     .:|.        ..|:    ||:|   ||    .::....|.|.:...|.|..:|.
Human   717 TIAV-----TQPS--------NTYKRKDVCWLN---WSNGSKPLLAFVVPALAIVAVNFVVVLLV 765

  Fly   379 VNHIMKIKSSVKSSTQQQRKCIQNNDFLLYLRLSVMMGVT---GISEVITYFVKRHKFWRQVLRV 440
            :..:.:.....:.|...:...|:....||.  |:.::|:|   ||..::.   .::..|..:..:
Human   766 LTKLWRPTVGERLSRDDKATIIRVGKSLLI--LTPLLGLTWGFGIGTIVD---SQNLAWHVIFAL 825

  Fly   441 PNFFHLGSGIVVFVLFILKRSTFQMIMERIS 471
            .|.|. |..|:.|.: :|.....|::..::|
Human   826 LNAFQ-GFFILCFGI-LLDSKLRQLLFNKLS 854

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl6NP_788473.1 Mth_Ecto 25..197 CDD:119403 43/212 (20%)
7tm_4 211..398 CDD:304433 43/219 (20%)
ADGRF1NP_722582.2 SEA 154..>215 CDD:279699
GPS 532..572 CDD:280071 7/44 (16%)
7tm_4 582..834 CDD:304433 57/280 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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