DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl6 and Adgrd1

DIOPT Version :9

Sequence 1:	NP_788473.1	Gene:	mthl6 / 38839	FlyBaseID:	FBgn0035789	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	NP_001074811.1	Gene:	Adgrd1 / 243277	MGIID:	3041203	Length:	903	Species:	Mus musculus

Alignment Length:	352	Identity:	73/352 - (20%)
Similarity:	127/352 - (36%)	Gaps:	78/352 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 FRYC--------EKVVSVQEDQYKLYENGSFMIKPDVNWTLSKQWYCLHPRLEDPNSIWILEHVY 197
            |.||        |.|.|.|         |..:.:.::.:::.   :|.|     ..:..||..|
Mouse   536 FLYCAFLNFSSGEGVWSSQ---------GCALTEGNLTYSVC---HCTH-----LTNFAILMQV- 582

  Fly   198 IPKSMPAVPQV--GTISMVGC----------ILTIAVYLYIKKLRNLLGKCFICYVFCKFV-QYL 249
            :|..:....||  .:||.|||          ::|.||...:..:||..........|...| |.|
Mouse   583 VPLKLTHGHQVALSSISYVGCSLSVLCLAATLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQVL 647

  Fly   250 IWAGGDLNLWNNICSLAGYTNYFFALASHFWLSVMSHQIWKNLRLINRDERSYHFLIYNIYGWGT 314
            :.....:......|.:.....::|.|.:..|:.|....::..:..:...|.|.|...|.| |||.
Mouse   648 LLISFSMEPGTVPCQVLAVLLHYFFLTAFAWMLVEGLHLYSMVIKVFGSEDSKHLYYYGI-GWGC 711

  Fly   315 PAIMTAITY---LVDWAWEDRPDKLNWIPGVGLYRCWINTYDWSAMIYLY-GPMLILSLFNVVTF 375
            |.::..|:.   :..:...|              .||:..  .|..|:.: ||.|::.:.|:|..
Mouse   712 PLLICIISISSSMDSYGTSD--------------SCWLAL--GSGAIWAFVGPALLVIVVNIVIL 760

  Fly   376 ILTVNHIMKIKS-SVK-----SSTQQQRKCIQNNDFLLYLRLSVMMGVTGISEVITYFVKRHKFW 434
            :.....|..|.: |.|     |:.:...|.:.  ..|..|..|.:.||..:|:       |...:
Mouse   761 VAVTRVISHISTDSYKIHGDPSAFKLTAKAVA--VLLPILGTSWVFGVLAVSD-------RALVF 816

  Fly   435 RQVLRVPNFFHLGSGIVVFVLFILKRS 461
            :.:..:.|..   .|:.:|:...|..|
Mouse   817 QYMFAILNSL---QGLFIFLFHCLLNS 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl6	NP_788473.1	Mth_Ecto	25..197	CDD:119403	12/63 (19%)
mthl6	NP_788473.1	7tm_4	211..398	CDD:304433	44/207 (21%)
Adgrd1	NP_001074811.1	Laminin_G_3	<173..273	CDD:290121
		GPS	539..579	CDD:280071	8/56 (14%)
		Stachel. /evidence=ECO:0000250\|UniProtKB:Q6QNK2	575..583		3/8 (38%)
		7tm_4	595..831	CDD:304433	54/264 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	862..903
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810