DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl6 and ADGRL2

DIOPT Version :9

Sequence 1:NP_788473.1 Gene:mthl6 / 38839 FlyBaseID:FBgn0035789 Length:480 Species:Drosophila melanogaster
Sequence 2:NP_001352934.1 Gene:ADGRL2 / 23266 HGNCID:18582 Length:1469 Species:Homo sapiens


Alignment Length:260 Identity:55/260 - (21%)
Similarity:107/260 - (41%) Gaps:47/260 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   208 VGTISMVGCILTIAVYLYIKKLRNLLGKCFICYVFCKFVQYLIWAGGDLNLWNNICSL-AGYTNY 271
            :..:.:..||.|...:..::..||.:.|.....:|  ..:::...|.|...:...|.: ||..::
Human   861 ISLVCLAICIFTFCFFRGLQSDRNTIHKNLCINLF--IAEFIFLIGIDKTKYAIACPIFAGLLHF 923

  Fly   272 FFALASHFWLSVMSHQIWKNLRLINRDERSY-HFLIYNIYGWGTPAIMTAITYLVDWAWEDRPDK 335
            || ||:..|:.:...|::  |.|:...|..| ....|.:.|:..||.:..::..:|:        
Human   924 FF-LAAFAWMCLEGVQLY--LMLVEVFESEYSRKKYYYVAGYLFPATVVGVSAAIDY-------- 977

  Fly   336 LNWIPGVGLYR-CWI---NTYDWSAMIYLYGPMLILSLFNVVTFILTVNHIMKIKSSVK--SSTQ 394
                ...|..: ||:   |.:.||    ..||:..:.|.|::..::|:..::|..:::|  ||..
Human   978 ----KSYGTEKACWLHVDNYFIWS----FIGPVTFIILLNIIFLVITLCKMVKHSNTLKPDSSRL 1034

  Fly   395 QQRKCIQNNDF--LLYLRLSVMMGVTGISE---VITYFVKRHKFWRQVLRVPNFFHLGSGIVVFV 454
            :..|......|  |..|.|:...|:..|:|   |:.|..             ..|:...|:.:|:
Human  1035 ENIKSWVLGAFALLCLLGLTWSFGLLFINEETIVMAYLF-------------TIFNAFQGVFIFI 1086

  Fly   455  454
            Human  1087  1086

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl6NP_788473.1 Mth_Ecto 25..197 CDD:119403
7tm_4 211..398 CDD:304433 42/194 (22%)
ADGRL2NP_001352934.1 Gal_Lectin 49..129 CDD:307994
OLF 142..398 CDD:321983
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 426..460
HormR 469..533 CDD:214468
GAIN 542..764 CDD:318649
GPS 788..840 CDD:197639
7tmB2_Latrophilin-2 848..1105 CDD:320672 55/260 (21%)
TM helix 1 850..875 CDD:320672 3/13 (23%)
TM helix 2 884..906 CDD:320672 4/23 (17%)
TM helix 3 915..942 CDD:320672 8/29 (28%)
TM helix 4 954..974 CDD:320672 4/19 (21%)
TM helix 5 991..1020 CDD:320672 8/32 (25%)
TM helix 6 1036..1063 CDD:320672 6/26 (23%)
TM helix 7 1067..1092 CDD:320672 5/33 (15%)
Latrophilin 1104..1469 CDD:308136
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1368..1410
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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