DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl6 and ADGRF2

DIOPT Version :9

Sequence 1:	NP_788473.1	Gene:	mthl6 / 38839	FlyBaseID:	FBgn0035789	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	NP_001355044.1	Gene:	ADGRF2 / 222611	HGNCID:	18991	Length:	708	Species:	Homo sapiens

Alignment Length:	256	Identity:	51/256 - (19%)
Similarity:	99/256 - (38%)	Gaps:	77/256 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 ILTIAVYLYIKKLRNLLGKCFICYVFCKFVQYLIWA------------------GGDL---NLW- 259
            |||...|:.       ||......:.|..::.|:|:                  ...|   ::|
Human   445 ILTYITYVG-------LGISICSLILCLSIEVLVWSQVTKTEITYLRHVCIVNIAATLLMADVWF 502

  Fly   260 ------------NNICSLAGYTNYFFALASHFWLSVMSHQIWKNLRLINRDERSYHFL------- 305
                        :..|..|.:..:||.|:..||:...:..|...:.::      :|.|
Human   503 IVASFLSGPITHHKGCVAATFFVHFFYLSVFFWMLAKALLILYGIMIV------FHTLPKSVLVA 561

  Fly   306 -IYNIYGWGTPAIMTAITYLVDWAWEDRPDKLNWIPGVGLYR---CWINTYDWSAMIYLYGPMLI 366
             :::: |:|.|..:.|||..   |.|         ||.|..|   ||:|.....|::....|.|.
Human   562 SLFSV-GYGCPLAIAAITVA---ATE---------PGKGYLRPEICWLNWDMTKALLAFVIPALA 613

  Fly   367 LSLFNVVTFILTVNHIMKIKSSVKSSTQQQRKCIQNNDFLLYLRLSVMMGVT---GISEVI 424
            :.:.|::|..|.:  :...::::.:|..|:.:.|......:.: |:.::|:|   |::.||
Human   614 IVVVNLITVTLVI--VKTQRAAIGNSMFQEVRAIVRISKNIAI-LTPLLGLTWGFGVATVI 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl6	NP_788473.1	Mth_Ecto	25..197	CDD:119403
mthl6	NP_788473.1	7tm_4	211..398	CDD:304433	44/225 (20%)
ADGRF2	NP_001355044.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900